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Immune system / Immunology / Monoclonal antibodies / Oncogenes / Monoclonal antibody therapy / Trastuzumab / HER2/neu / Bi-specific T-cell engager / Insulin-like growth factor 1 receptor / Biology / Anatomy / Tyrosine kinase receptors


Brief Report mAbs 5:2, 208–218; March/April 2013; © 2013 Landes Bioscience Monoclonal antibody therapeutics with up to five specificities
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Document Date: 2013-06-10 17:56:01


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City

Trastuzumab / TRA / Cetuximab / /

Company

IgG / Thermo Fisher / LG / Zyngenia Inc. / Taconic Farms Inc. / Blue Door Pharma / Grinnell / Thermo Electron / MRD / GE Healthcare / BD Biosciences / Harlan Laboratories / Im SA / PerkinElmer / IDT Technologies / KPL Inc. / /

Country

United States / /

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Event

M&A / /

Facility

Skaggs Institute / scaffold MRD / Scripps Research Institute / /

IndustryTerm

serum-free media / chemical approach / multi-valent technology / antigen binding site / animal protocols / adalimumab heavy chain / light chain / treatment of human disease / sensor chip / /

MedicalCondition

arthritis / chronic lymphocytic leukemia / ErbB2- and angiogenesis-dependent xenograft tumor / human tumor / early breast cancer / J Cancer / pancreatic adenocarcinoma cell line / metastatic breast cancer / xenograft tumor / human diseases / metastatic breast cancers / few human diseases / tumor / Cancer / Female NOD/SCID / angiogenesis-dependent xenograft tumor / tumors / disease / also mediate solid tumor / diseases / human disease / /

MedicalTreatment

oncology therapies / /

Organization

2The Skaggs Institute for Chemical Biology and the Departments of Molecular Biology and Chemistry / Institutional Animal Care and Use Committee / Scripps Research Institute / /

Person

David W. LaFleur / Carlos F. Barbas / Elvin Ng / Anton Nguyen / Ella Biotec / Carlos F. Barbas / III / /

Product

Humira / Synagis / Herceptin / sodium chloride / HEK293-F suspension / glycine / Tao / Erbitux / HEK293F suspension / /

ProgrammingLanguage

ADA / /

PublishedMedium

Molecular Biology / /

RadioStation

Wurm FM / /

Technology

alpha / CM5 sensor chip / multi-specific / multi-valent technology / antibodies / Biotechnology / SPR sensor chip / Cell Signaling / pharmacokinetics / phage display / Weblogo algorithms / http / animal protocols / CAT / /

URL

http /

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