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Signal transduction / Transcription factors / Tumor necrosis factor-alpha / Bone morphogenetic protein / Mitogen-activated protein kinase / RUNX2 / Interleukin / Crosstalk / Mothers against decapentaplegic homolog 1 / Biology / Cell biology / Cytokines


Opposing TNF-α/IL-1β- and BMP-2-activated MAPK signaling pathways converge on Runx2 to regulate BMP-2-induced osteoblastic differentiation
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Document Date: 2014-04-17 09:59:59

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File Size: 2,90 MB

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City

Shanghai / Nanjing / Lianyungang / San Diego / Lincoln / St. Louis / Santa Cruz / /

Company

GE / Shanghai Key Laboratory / Simmons / Macmillan Publishers Limited / /

Country

United States / China / /

Currency

VND / /

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Event

FDA Phase / /

Facility

Shanghai Cancer Institute / Nanjing Jiancheng Bioengineering Institute / Shanghai Jiao Tong University / Shanghai Ninth People’s Hospital / Wenxuan Medicine Building / Shanghai Key Laboratory of Orthopaedic Implants / /

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IndustryTerm

implantation site / infrared imaging system / alkaline solution / /

MedicalCondition

inflammatory response / soft-tissue inflammation / ankylosing spondylitis / rheumatoid arthritis / inflammatory cytokines TNF-a / inflammatory cytokines / inflammatory environment / inflammatory cells / inflammatory diseases / inflammatory bone resorption / Trauma-induced inflammation / Disease / inflammatory and anti-inflammatory cytokines / recurrent unicameral bone cysts / Cytokine-mediated inflammatory reaction / Tumor necrosis / exaggerated inflammatory environment / Exaggerated inflammatory response / osteoporosis / Fullmer N. Vertebral bone resorption / inflammation / inflammatory responses / inflammatory / subaxial degenerative spine disease / /

MedicalTreatment

spine surgery / Neurosurgery / Plastic and Reconstructive Surgery / spinal surgery / /

Organization

Department of Plastic / Shanghai Jiao Tong University School of Medicine / corticosteroids21 / 22 Department / Department of Plastic and Reconstructive Surgery / Shanghai Ninth People’s Hospital / National Natural Science Foundation of China / Ministry of Science and Technology of China / Nanjing Jiancheng Bioengineering Institute / European Union / Shanghai Cancer Institute / Shanghai Jiao Tong University / Shanghai / /

Person

Alexa Fluor / Karin M. Mammalian / /

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Position

Bone Miner / China *Corresponding author / Dual Luciferase Reporter / Workman / representative / reporter / /

Product

dexamethasone / penicillin / IL-1b / Smad1 siRNA / amphotericin B / BMP-2 / rhBMP-2 / s / /

ProvinceOrState

Maryland / South Dakota / /

PublishedMedium

PLoS One / /

RadioStation

Tidball AM / Surg Am 2012 / Morgan AM / /

Technology

alpha / BMP / antibodies / siRNA / Biotechnology / Cell Signaling / stem cells / DNA binding / Technology of China / Biomaterials / Neurosurgery / /

URL

www.nature.com/cddis / /

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