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Medicine / Immunology / T cells / Antivirals / Interleukin 12 / Interleukin / T helper cell / HER2/neu / Interferon-gamma / Biology / Immune system / Cytokines


IL-12 enhances the natural killer cell cytokine response to Ab-coated tumor cells Robin Parihar,1,2 Julie Dierksheide,3 Yan Hu,2 and William E. Carson1,2,3 1Department of Molecular Virology, Immunology, and Medical Gene
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City

San Francisco / Systemic / Fullerton / Memphis / Columbus / Vancouver / ERB / P30 / St. Louis / Francisco / Rockville / Barcelona / Woburn / Minneapolis / Valencia / RANTES / Scott / Louis / Cambridge / Herceptin / Foster City / TNF / Germantown / /

Company

Endogen Inc. / anti-HER2 Ab / Genetics Institute Inc. / Becton Dickinson and Co. / Life Technologies Inc. / Hooker N.A. / Sigma-Aldrich / Wilson / Qiagen Inc. / Genentech Inc. / Hoffman-LaRoche Inc. / Fleming / IgG / Kraft / The Jackson Laboratory / Beckman Coulter / PeproTech Inc. / R&D Systems Inc. / /

Country

Canada / United States / Spain / /

Currency

pence / /

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Event

FDA Phase / /

Facility

Bar Harbor / The Ohio State University College of Medicine / Ohio State University Comprehensive Cancer Center / Jude Children’s Research Hospital / Ohio State University / N924 Doan Hall / Hospital Universitari Vall D’Hebron / /

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IndustryTerm

control groups / food / tumor site / treatment of advanced breast cancer / treatment for regional breast cancer / human cancer therapy / /

MedicalCondition

normal huIgG-treated tumor / ovarian cancer / human breast adenocarcinoma / Infectious stimuli / mAb-mediated tumor / human tumors / Combined allogeneic tumor / HER2-overexpressing tumor / experimental tumor / 3LL-A9 Lew carcinoma / huIgG-treated tumor / advanced breast cancer / Breast cancer / CT-26HER2/neu murine tumor / tumor / colon carcinoma / regional breast cancer / Cancer / HER2-overexpressing tumors / tumors / mice bearing breast cancer / early inflammatory responses / J. Cancer / human cancer / spontaneously metastatic mammary adenocarcinoma / spontaneous metastases / HER2+ tumor / Herceptincoated tumor / Her2/neu-positive breast cancer / murine tumor / mammary carcinogenesis / her2/neu-overexpressing metastatic breast cancer / lymphoma / established tumors / solid tumors / human adenocarcinomas / metastatic breast cancer / Ab-coated tumor / murine colon carcinoma / both infectious stimuli / human breast cancer / human breast adenocarcinoma lines / direct tumor / HER2-expressing tumor / human HER2/neu expressing tumors / HER2-positive tumor / /

MedicalTreatment

vaccination / Surgery / surgical treatment / cancer therapy / chemotherapy / /

Organization

The Ohio State University College of Medicine / the Ohio State University / National Institute of Health / American Red Cross / Arthur G. James Comprehensive Cancer Center / Administration of Herceptin / Ohio State University Department of Surgery / Jude Children’s Research Hospital / Ohio State University / Columbus / Ohio State University Comprehensive Cancer Center / IL-12 administration / CCC Animal Care and Use Committee / /

Person

Nat / Robin Parihar / Gene Ther / G. James Comprehensive / Jose Baselga / James Ihle / Arthur G. James / /

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Position

representative / Walker / MMLV-RT / Hunter / /

Product

Herceptin / cisplatin / IL-12 / Hypaque / CT-26 / penicillin / amphotericin B / IL-2 / 2B1 / MDX210 / Ab-coated / /

ProvinceOrState

Ohio / Minnesota / Virginia / Maine / British Columbia / Missouri / California / New Jersey / Wisconsin / Maryland / South Dakota / Tennessee / Massachusetts / /

PublishedMedium

The Journal of Clinical Investigation / /

Technology

Stem Cells / apoptosis / chemotherapy / treating cancer / alpha / antibodies / /

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