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Cytokines / Immune system / Lymphocytes / Proteins / NF-κB / Natural killer cell / IKBKG / Interleukin / Antibody-dependent cell-mediated cytotoxicity / Biology / Anatomy / Cell biology


Deficient natural killer cell cytotoxicity in patients with IKK-γ/NEMO mutations Jordan S. Orange,1 Scott R. Brodeur,1 Ashish Jain,2 Francisco A. Bonilla,1 Lynda C. Schneider,1 Roberto Kretschmer,3 Samuel Nurko,1 Wendy
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Document Date: 2008-08-28 21:37:44

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City

South San Francisco / Piscataway / Iowa City / Dartford / Portland / Bethesda / Ozes / San Jose / Charlottesville / Emeryville / Minneapolis / Mexico City / Boston / New York / Madison / Cambridge / San Diego / /

Company

PerkinElmer Inc. / Becton Dickinson Immunocytometry Systems / Chiron Corp. / Amersham / Promega Corp. / Genentech Inc. / Perkin-Elmer Inc. / CCI / Murex Biotech Ltd. / IgG / GenBank / R&D Systems Inc. / /

Country

United Kingdom / Mexico / United States / /

Currency

pence / /

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Event

Product Issues / /

Facility

Hospital ABC / Children’s Hospital / Oregon Health Sciences University / Harvard University / University of Virginia / National Institute of Allergy / Hospital General Clinical Research Center M01-RR02172 / IKK complex / /

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MedicalCondition

ectodermal dysplasia / Klebsiella pneumoniae bacteremia / tumour necrosis / murine cytomegalovirus infection / diphtheria / Neither disease / virus infections / immune deficiency / Severe herpesvirus infections / illness / X-linked hypohidrotic ectodermal dysplasia / tumor / pneumonia / HED-like syndrome / recurrent infection / severe recurrent herpesvirus disease / CMV infection / disseminated varicella / Streptococcus bovis meningitis / Serum tetanus / delayed-type hypersensitivity / infectious susceptibility / virus infection / Incontinentia pigmenti / certain viral infections / infection / deficiency / granulomatous chronic vertebral osteomyelitis / Infectious Disease / sensitive erythroleukemia cell line / herpesvirus infections / resistant murine lymphoma cell line / recurrent cytomegalovirus infections / Anhidrotic ectodermal dysplasia / autosomal recessive and dominant hypohidrotic ectodermal dysplasia / severe Epstein-Barr virus infections / recurrent sinopulmonary infections / tetanus / novel X-linked disorder / non-x-linked syndrome / herpes / hyper-IgM syndrome / specific antibody deficiency / adenitis / delayed hypersensitivity / CMV colitis / rare syndrome / sinusitis / X-linked syndrome / skin hyperpigmentation / cutaneous granulomas / sepsis / mycobacterial and streptococcal infections / Disease / transient hypogammaglobulinemia / recurrent and severe herpes / certain infectious disease / hypohydrotic ectodermal dysplasia / CMV disease / persistent viral infection / Killer (NK) cell deficiency / recurrent herpes simplex encephalitis / hypohidrotic ectodermal dysplasia / gram-positive bacteremia / acute myelogenous leukemia / human disease / X-linked anhidrotic ectodermal dysplasia / /

MedicalTreatment

immunizations / immunoglobulin therapy / intravenous infusion / /

Organization

United States Public Health Service / Oregon Health Sciences University / Department of Internal Medicine / University of Virginia / National Institute of Allergy and Infectious Diseases / Committee on Clinical Investigation / Harvard Medical School / National Institute of Health / Harvard University / Department of Pediatrics / Division of Immunology / Children’s Hospital / IL-2 administration / National Center for Research Resources / Mexico 4Iowa City Veterans Administration / /

Person

Nat / Mansour / Headon / Raif S. Geha / Jordan S. Orange / Scott R. Brodeur / /

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Position

General / D.J. / representative / Harper / /

Product

IL-12 / Hypaque / penicillin / IL-2 / CD40 signaling / NEMO signaling / /

ProvinceOrState

Minnesota / Virginia / New York / California / New Jersey / Wisconsin / Maryland / Oregon / O.N. / Iowa / Massachusetts / /

PublishedMedium

The Journal of Clinical Investigation / Molecular Biology / /

Technology

gene expression / antibodies / artificial intelligence / /

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