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Racetams / Membrane biology / Ionotropic receptors / Cell signaling / AMPA receptor / Receptor / Glutamate receptor / AMPA / Aniracetam / Biology / Cell biology / Ampakines


Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain
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Document Date: 2013-11-07 17:53:20


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Ballerup / Madison / Lund / Copenhagen / London / /

Company

Cellscript Inc. / Kristensen A. S. / DanPET AB / Johnson S. A. / NeuroSearch A/S / Storoni L. C. / Broberg B. V. / Novo Nordisk / /

Country

Sweden / United States / Denmark / /

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pence / /

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Facility

Me-CX516 complex / CX516 complex / University of Copenhagen / /

IndustryTerm

agonist-binding site / low-energy conformation / low-energy conformations / conformational search / ml crystallization solution / aromatic ring systems / search model / protein solution / methyl / stock solutions / crystallization solution / ml protein solution / lowest energy conformations / mM stock solutions / /

MedicalCondition

Alzheimer’s disease / cognitive disorders / /

Movie

A. I. / /

Organization

Faculty of Health and Medical Sciences / Department of Drug Design and Pharmacology / International Union of Crystallography Printed in Singapore / University of Copenhagen / /

Person

Karla Frydenvang / Linda G. Zachariassen / Chen / V / Heidi Peterson / Jørgen Bach Pedersen / Tove Thomsen / Keedy / Gitte Friberg / /

Product

sodium acetate / GluA2 LBD-L483Y-N754S / diazoxide / Nikon D60 Digital Camera / /

ProvinceOrState

Wisconsin / /

Technology

radiation / X-ray / crystallization / Drug Design / flash / /

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