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City Oxford / Tokyo / Mannheim / Cambridge / Bethesda / London / Darmstadt / / Company Millipore / Sigma-Aldrich / Leica Microsystems GmbH / Huntsman / Pfizer / JEOL Ltd / Storey SA / GE Healthcare / Wiley Periodicals Inc. / / Country Germany / Sweden / Japan / United States / United Kingdom / / Facility National Institute of Mental Health / University College London / Wiley Online Library / / IndustryTerm pharmaceutical development / oil immersion objective / biotechnology / downstream processing / feed solution / imaging / anion-exchange chromatography media / storage ethanol solution / large-scale manufacturing runs / live imaging / largescale manufacturing / data processing / Image processing / condition media / desired product / Online Library / analytical tool / chemicals / / Organization University College London / Department of Biochemical Engineering / Department of Chemical Engineering / Centre for Process Systems Engineering / Engineering and Physical Sciences Research Council for the IMRC / US Food and Drug Administration / Advanced Centre for Biochemical Engineering / FDA / National Institute of Mental Health / / Person Edward J. Close / Shepard SR / / / Position fully fouled resin representative / representative / reporter / / Product sodium chloride / calcium chloride / / ProvinceOrState Maryland / / RadioStation Lenhoff AM / / Technology antibodies / Biotechnology / high-throughput screening / Image processing / ion exchange / laser / lasers / spectroscopy / Bioprocessing / / URL http / SocialTag 
ARTICLE Fouling of an Anion Exchange Chromatography Operation in a Monoclonal Antibody Process: Visualization and Kinetic Studies Edward J. Close,1,2 Jeffrey R. Salm,3 Timothy Iskra,3 Eva Sørensen,2 Daniel G. Bracewell1