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Membrane biology / Protein kinases / Signal transduction / JTV-519 / Ryanodine receptor / Calcium channel / Ruthenium red / Ca2+/calmodulin-dependent protein kinase / Protein kinase A / Biology / Ion channels / Integral membrane proteins


Inaugural Article: Ryanodine receptor/calcium release channel PKA phosphorylation: A critical mediator of heart failure progression Xander H. T. Wehrens, Stephan E. Lehnart, Steven Reiken, John A. Vest, Anetta Wronska, a
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Document Date: 2006-10-01 16:31:39

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City

Piscataway / Williams / Cannell / Hercules / Falls Church / Hamden / Boston / Tokyo / La Jolla / L. A. / San Diego / St. Louis / /

Company

Hewlett Packard / Bernstein / Furukawa / ischemic HF / Belevych A. E. / S. L. C. / post-MI HF / Bio-Rad / Obayashi / McCune S. A. / Amersham Pharmacia Biosciences / Google / /

Country

United States / Columbia / /

Currency

pence / USD / /

/

Event

Product Issues / FDA Phase / /

Facility

Columbia University / PKA complex / RyR2 complex / College of Physicians / /

IndustryTerm

oil immersion objective / charge carrier / stop solution / Chamber solutions / phosphorylation site / model systems / perfusion solution / /

MedicalCondition

dysfunction / cardiac dysfunction / bradycardia / calstabin2 dissociation / hypotension / dissociation / PDE4D deficiency / fatal cardiac arrhythmias / complex systemic syndrome / ventricular dysfunction / sudden cardiac death / progressive cardiac dysfunction / shortness of breath / cardiac arrhythmias / sudden cardiac death H / stroke / rabbit heart failure / chronic activation / lethargy / chronic SNS activation cause PKA / chronic hyperadrenergic state / myocardial infarction / heart failure / Wehrens et al. progressive cardiac dysfunction / complex multifactorial disorder / depression / impotence / enhanced cardiac dysfunction / namely dissociation / /

MedicalTreatment

Cardiac catheterization / catheter / /

NaturalFeature

Po / /

Organization

Institutional Animal Care and Use Committee / Helen Wu Center for Molecular Cardiology / National Academy of Sciences / Columbia University / New York / Leducq Foundation / College of Physicians and Surgeons / /

Person

Andrew R. Marks / Nat / W. J. Lederer / Ai / Steven Reiken / Stephan E. Lehnart / Mutagenesis Kit (Stratagene) / John A. Vest / Mancini / /

Position

mediator / critical mediator / Heart Association National Scientist Development grants / Representative / /

Product

isoflurane / RyR2S2808A / tACE / RyR2 / regulation / SR Ca2 / /

ProgrammingLanguage

C / /

ProvinceOrState

Alabama / New York / Michigan / South Carolina / Nova Scotia / M. B. / /

Technology

antibodies / directed mutagenesis / ultrasound / laser / recombination / flash / /

URL

www.pnas.org/cgi/content/full/0510113103/DC1 / www.pnas.org/cgi/collection/inaugurals / www.pnas.org/misc/reprints.shtml / www.pnas.org/cgi/content/full/103/3/511#BIBL / www.pnas.org/cgi/content/full/103/3/511 / www.pnas.org/cgi/content/full/103/24/8915 / www.pnas.org/cgi/content/full/103/3/511#otherarticles / www.pnas.org/misc/rightperm.shtml / www.pnas.org!cgi!doi!10.1073!pnas.0510113103 / /

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