| Document Date: 2013-08-06 05:57:45
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City Boston / Cambridge / L.A. / / Company Agilent Technologies / Qiagen / IDT / Cox / / Country Mali / United States / / Currency pence / / / Event Product Issues / / Facility C terminus / C terminus of Cas9N / Cas9 complex / Stimulate library / Harvard University / / IndustryTerm nucleotide composition nature biotechnology / online version / biological systems / validity processing / genome engineering tools / eukaryotic systems / advance online publication nature biotechnology Online Methods Plasmid construction / library sequence processing / transcription start site / nature biotechnology / nuclease applications / energy / end-processing enzymes / transcriptional start site / advance online publication nature biotechnology / target site / sites nature biotechnology / genome engineering applications / gene cDNA sequence processing / advance online publication / transcriptional regulation applications / therapeutic applications / genome editing tool / / MarketIndex set 250 / / MusicGroup M.E. / / Organization Harvard Medical School / Harvard University / Department of Energy / 2Wyss Institute / / Person Nat / / Position SSC Reporter / promoter-luciferase reporter / aptamer 2X SSC Reporter / Author / successfully activated reporter / reporter / / Product Cowon D2+ Portable Audio Device / Cas9 / / ProgrammingLanguage Perl / php / / ProvinceOrState S.K. / Nova Scotia / Massachusetts / / Technology biotechnology / cloning / Perl / stem cells / DNA binding / DNA binding system / human genome / directed evolution / gene expression / Gene targeting / recombination / FLASH / / URL http /
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letters CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering Prashant Mali1,4, John Aach1,4, P Benjamin Stranges1, Kevin M Esvelt2, Mark Moosburner1, Sr