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Peptide hormones / Obesity / Intracellular receptors / Leptin / Genetics of obesity / Insulin / Adipose tissue / Ob/ob mouse / Melanocortin 4 receptor / Biology / Diabetes / Nutrition


European Journal of Endocrinology[removed]–441 ISSN[removed]INVITED REVIEW
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Document Date: 2002-10-03 03:00:00

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City

New York / Savage / Cambridge / /

Company

Sina / Fairchild / Hexagen / Wellcome Trust / Incyte / Wilson TM & Kliewer SA. / New England Journal / Cox / Krisha / Suzuki / Jebb SA / Gharavi AG / /

Country

United Kingdom / /

Currency

pence / /

/

Event

Product Issues / Business Partnership / /

Facility

Addenbrooke’s Hospital / University of Cambridge / /

IndustryTerm

industrial-scale applications / biotechnology / deviation score Online version / impaired prohormone processing / neural network / endocrine processing events / /

MedicalCondition

common metabolic disorders / common genetic diseases / particular disease / upper limb lipodystrophy / extreme insulin resistance / selective post-receptor insulin resistance / human hypertension / severe obesity / JE / early obesity / severe insulin resistance / autosomal dominant obesity / congenital lipodystrophy / O’Rahilly S. Severe insulin resistance / severe early-onset obesity / thyroid hormone resistance syndrome / beneficial Obesity / maturity-onset diabetes / complex disorder / hyperphagia Hypogonadotrophic hypogonadism Short stature Central hypothyroidism / particular hormone deficiency / obesity / idiopathic hypogonadotrophic hypogonadism / familial partial lipodystrophy / ultimately fatal congenital diarrhoeal illness / disorder / human morbid obesity / Monogenic obesity / hypogonadism / juvenile obesity / common diseases / Face-sparing lipodystrophy Partial lipodystrophy / small bowel dysfunction / early-obesity human obesity / leptin deficiency / partial adrenocorticotrophin deficiency / partial lipodystrophy / MCR4 deficiency / receptor deficiency / insulin resistance / Intrauterine growth retardation / lipodystrophy / hypertension / Donohue’s syndrome / disease / congenital leptin deficiency / human obesity / 11q13-linked congenital generalized lipodystrophy / diabetes / pseudohypoparathyroidism / cohort Unlike obesity / human leptin deficiency / acanthosis nigricans / extreme obesity / Partial leptin deficiency / diabetes mellitus / commonest single-gene disorder / rare disorders / diseases / monogenic disorders / skin lesion acanthosis nigricans / both beta cell dysfunction / fatty liver / metabolic disease / syndrome / disorders / obesity study / thyroid hormone resistance / common endocrine disorders / morbid obesity / /

MedicalTreatment

pharmacotherapy / /

Organization

Addenbrooke’s Hospital / Internal Revenue Service / Bristol Myers Squibb Foundation / UK Medical Research Council / University of Cambridge / /

Person

Maria Soos / Sadaf Farooqi / Anna Krook / Gene Major / Siegfried Wet al / John Wiley / Van Maldergem / /

/

Position

Butler / Stewart PM / final mediator / /

Product

Pseudo / activation / intracellular transport / /

PublishedMedium

American Journal of Human Genetics / Molecular and Cellular Biology / Journal of Clinical Investigation / Nature Genetics / the European Journal / Endocrinology / New England Journal of Medicine / Journal of Endocrinology / /

Region

New England / /

Technology

alpha / Genomics / antibodies / biotechnology / positional cloning / gene analysis / neural network / /

URL

www.eje.org / http /

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