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Drug rehabilitation / Amines / Piperazines / Torsades de pointes / QT interval / Methadone / Long QT syndrome / Dofetilide / Buprenorphine / Chemistry / Organic chemistry / Cardiac dysrhythmia


Clinical Guidelines Annals of Internal Medicine QTc Interval Screening in Methadone Treatment Mori J. Krantz, MD; Judith Martin, MD; Barry Stimmel, MD; Davendra Mehta, MD; and Mark C.P. Haigney, MD
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San Francisco / Tucson / Durrheim / Derby / Paris / Columbus / Santiago / Cleveland / Toronto / Bethesda / Yardley / Denver / Rockville / New York / Nuzzo / Augusta / Copenhagen / London / /

Company

Agency for the Evaluation / Purdue Pharma / Boston Scientific / ECG Core Laboratory / Directors / Human Resources / Reckitt Benckiser / Addiction Recovery Services / Fahrig SA. / Catalyst Pharmaceutical Partners / GE / Roxane Laboratories / Medtronic / Pearson / MEDLINE / Reckitt Benckiser Pharmaceuticals / Shimizu / Suzuki / Western Clinical Health Services / /

Country

United Kingdom / Denmark / Italy / Northern Ireland / United States / /

Currency

pence / /

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Event

Product Recall / Product Issues / /

Facility

FDA Center / Uniformed Services University / University of Arizona Center / Colorado Prevention Center / University of Colorado / MCV Campus / American College of Physicians / BAART Turk Street Clinic / /

IndustryTerm

retail pharmacies / treatment services / /

MedicalCondition

torsades de pointes / seizures / Drug-induced arrhythmia / congenital long QT syndrome / detectable cardiac disease / significant arrhythmia / cardiac arrhythmia / recurrent arrhythmia / bradycardia / Devriendt J. Torsades de pointes / generalized seizures / liver disease / prolonged QT syndrome / Parker M. Torsades de pointes / Methadoneinduced torsade de pointes / sudden cardiac death / Karir V. Bradycardia / catastrophic arrhythmia / complete atrioventricular block / ventricular fibrillation / respiratory depression / hypokalemia / Culclasure T. Methadone-induced bradycardia / chronic pain / recurrent torsade de pointes / unexplained syncope / methadone-induced long QT syndrome / Drug-induced long QT syndrome / syncope / torsade de pointes / both chronic pain / congenital long-QT syndrome / long QT syndrome / arrhythmia / heroin users / congestive heart failure / early sudden cardiac death / tachycardias / greater arrhythmia / acute respiratory distress syndrome / cardiac arrhythmias / pain / drug abuse / structural heart disease / terminal / intractable cancer pain / methadone-related torsade de pointes / overt torsade de pointes / Cocaine-related torsade de pointes / chronic methadone therapy / heroin dependence / /

MedicalTreatment

Pharmacotherapy / antiretroviral therapy / alternative therapy / pain management / /

Organization

Maine office of Substance Abuse / U.S. Department of Health and Human Services / Committee for Proprietary Medicinal Products / Dept of Health / Department of Epidemiology / National Institute on Drug Abuse / American Society of Addiction Medicine / Research office of Surveillance and Epidemiology / Drexel University / Case Western Reserve University School of Medicine / FDA Center for Drug Evaluation / American Association for the Treatment of Opioid Dependence / Sinai School of Medicine / Department of Health / Substance Abuse and Mental Health Services Administration office of Applied Studies / Welsh Assembly Government / Center for Substance Abuse Treatment / Amsterdam EA / Department of Epidemiology and Community Health / Uniformed Services University of the Health Sciences / University of Colorado / Scottish Government / Virginia Commonwealth University School of Medicine / European Agency for the Evaluation of Medicinal Products / Association of Methadone / Prevention Department / U.S. Food and Drug Administration / University of Arizona Center for Education / CDER office of Surveillance and Epidemiology / Center for Drug Evaluation and Research / Department of Defense / American College of Physicians / Substance Abuse and Mental Health Services Administration / Medicines and Healthcare products Regulatory Agency / American Association for the Treatment / Colorado Prevention Center / /

Person

Robert Rappaport / Margaret Kotz / Mayo Clin Proc / Barry M. Methadone / Davendra Mehta / Interest / Frank Vocci / Ann Intern Med / Mayo D. Chronic / Laura Governale / Ann Fr Anesth Reanim / Mark C.P. Haigney / Mori J. Krantz / Br J Hosp Med / Arch Intern / Judith Martin / Sara Alan / Ann Cardiol Angeiol / Barry Stimmel / DO / Powell Golay / Ann Intern / Ann Pharmacother / William Baker / Keeffe / Silver Spring / /

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Position

Director / BAART Turk Street Clinic / physician / author / Professor / President and CEO / Executive / Davis MP / representative / investigator / Editor / Walker / Medical Director / Associate Professor of Medicine / Consultant / Treatment cardiologist / Director / Division of Pharmacotherapies & Medical Consequences / Dean / Director of Electrophysiology / cardiologist / Governor / Director / Director of Cardiology and Electrophysiology and Professor of Medicine / chair / Porter / Director / Division of Anesthesia / /

Product

FS / fentanyl / Dolophine Hydrochloride / methadone hydrochloride / Orlaam / drug / adenosine / /

ProvinceOrState

Ohio / Minnesota / Maine / New York / New Mexico / California / Arizona / Colorado / Ontario / Hennepin County / Maryland / Pennsylvania / North Carolina / /

RadioStation

Malas AM / Patel AM / /

Technology

alpha / pdf / Pharmacokinetics / drug development / /

URL

www.fda.gov / www.csdp.org/research/methadone.samhsa204.pdf / www.azcert.org / www.fda.gov/cder/foi/label/2006/006134s028lbl.pdf / www.maine.gov/dhhs/osa/pubs/osa/2003/drugreport.pdf / www.annals.org / www.dpt.samhsa.gov/pdf/Methadone_Report_10%2018%2007 / www.fda.gov/cder/drug/shortages/orlaam.htm / www.thomsonhc.com / http /

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