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Neutron moderators / Fatty acids / Kinetic isotope effect / Physical organic chemistry / PTGS2 / Lipoxygenase / Fatty acid metabolism / Hydrogen peroxide / Enzyme kinetics / Chemistry / Chemical kinetics / Enzymes


Published on WebCatalytic Mechanism of a Heme and Tyrosyl Radical-Containing Fatty Acid r-(Di)oxygenase Arnab Mukherjee, Alfredo M. Angeles-Boza, Gregory S. Huff, and Justine P. Roth* Department of Chemistry
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Document Date: 2011-03-11 10:27:38


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File Size: 1,33 MB

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Cukier / New York / Pittsburgh / Durham / /

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Porter N. A. / Cambridge Isotope Laboratories / Siletsky S. A. / Seibold S. A. / Sigma-Aldrich / Gaussian Inc. / Tyr379Phe / Agilent / Synergy Software / Wilson / COX / Yellow Springs Inc. / Friedman A. E. / RRO / Simmons / /

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United States / /

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Facility

Plant Physiol / C. Arch / Texas A&M University Protein Chemistry Facility / I. Arch / Johns Hopkins UniVersity / Michaelis complex / R. J. Arch / /

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active site / aldehyde products / isotopic zero-point energy differences / hydroperoxide product / free energy barrier / aldehyde product / oxidized prosthetic / protein solutions / energy difference / longer chain / detectable products / Chemical reagents / anaerobic solution / zero-point energy / Substrate-containing solutions / detectable product / zeropoint energy differences / isotopic nonaldehyde products / prosthetic / energy-minimized structures / thermal activation energy / /

Organization

Justine P. Roth* Department of Chemistry / Johns Hopkins UniVersity / American Chemical Society / Texas A&M University / O2 association / /

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Justine P. Roth / Gregory S. Huff / Arnab Mukherjee / Alfredo M. Angeles-Boza / Dkcat / Gq / Williams / Miller / V / /

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General / T. D. / V. P. / Fisher / /

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iRiver E30 Portable Audio Device / /

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Tyr379 / Pennsylvania / Rhode Island / /

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236 J. AM / 230 J. AM / 232 J. AM / 234 J. AM / J. AM / 228 J. AM / /

Technology

directed mutagenesis / Computational Chemistry / cell signaling / thermodynamics / spectroscopy / gas chromatography / gel electrophoresis / dialysis / /

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