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Oncogenes / Tyrosine kinase receptors / Apoptosis / Programmed cell death / Kruppel-like factors / KLF4 / Lapatinib / Trastuzumab / Myc / Biology / Medicine / Transcription factors


Regulation of anti-apoptotic signaling by Kruppel-like factors 4 and 5 mediates lapatinib resistance in breast cancer
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Document Date: 2015-03-19 09:33:20


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File Size: 3,12 MB

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GEMMs / Life Technologies / Millipore / Qiagen / GE Healthcare / BD Biosciences / Jax Labs / Cox / Macmillan Publishers Limited / /

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United States / /

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FDA Phase / /

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Bar Harbor / Whitehead Institute / West Virginia University Health Sciences Center / University Health Sciences Center / National Cancer Institute / Mary Babb Randolph Cancer Center / West Virginia University / Baylor College of Medicine / /

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distal binding site / therapy of metastatic disease / sample processing / treatment of HER2-positive breast cancer / fluorescence microscopic imaging / Statistical programming software / transcriptional start site / /

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inflammatory breast cancer cell line / luminal tumors / mammary cancer / basal tumors / primary breast tumors / mouse model tumors / intrinsically aggressive breast cancers / spontaneous tumors / human tumor / human tumors / human HER2enriched breast cancer / metastatic disease / luminal and non-luminal tumors / different breast cancer / patients harboring tumors / primary human breast cancers / For HER2+ breast cancer / single breast tumor / serum starvation / patient breast tumors / breast cancer / tumor / negative breast cancer / cancer / tumors / HER2-enriched tumors / Neu tumors / mesenchymal subgroup tumors / overall mean tumor / human breast tumors / cultured tumor / breast tumors / HER2+ breast cancers / primary human breast tumors / HER2-amplified tumor / GEMM tumors / previously described breast cancer / HER2-positive breast cancer / breast cancer MK Farrugia1 / M6 breast cancer / Mouse breast tumors / myeloid cell leukemia / HER2+ tumors / hematological malignancies / HER2enriched tumors / anti-apoptotic factors myeloid cell leukemia / basal-like/claudin-low tumors / mouse mammary tumor virus promoter / predominantly luminal tumors / In breast cancer / MMTV-Neu tumors / HER2enriched breast cancer / luminal breast cancer / human breast cancer / different human breast cancer / primary tumors / mammary carcinoma / HER2+ cancers / Disease / normal breastlike tumors / mammary tumors / myeloid leukemia / basal-like tumors / HER2-enriched breast cancer / TAg tumors / B-cell lymphoma / mammary tumor / /

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Charles River / /

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Division of Biostatistics / BCL2 / Mary Babb Randolph Cancer Center / National Cancer Institute / 3The Mary Babb Randolph Cancer Center / Whitehead Institute / West Virginia University / Baylor College of Medicine / Houston / Department of Biochemistry / West Virginia University Health Sciences Center / Duncan Cancer Center / /

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Afsaneh Keyhani / Dan L Duncan / Robert A Weinberg / Roger Davis / Frederick / Jeffrey E Green / /

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previously described translation reporter / *Corresponding author / The pMIR-Report-Luc-KLF4-FL translation reporter / Fisher / reporter / /

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Herceptin / RNAseq / penicillin / sterile water / HER2 / /

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West Virginia / California / Texas / South Dakota / /

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West Virginia / /

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approved ACUC protocol / siRNA / stem cells / apoptosis / DNA Chip / gene expression / 3g / gel electrophoresis / antibodies / KLF4/5 ChIP / Cell Signaling / /

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www.nature.com/cddis / http /

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