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Genetics / DNA-PKcs / Molecular genetics / Ataxia telangiectasia mutated / Protein kinase C / Ku80 / P53 / H2AFX / Non-homologous end joining / Biology / DNA repair / Proteins


Mutual regulation between DNA-PKcs and snail1 leads to increased genomic instability and aggressive tumor characteristics
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Document Date: 2013-02-28 09:58:35


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File Size: 2,49 MB

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DNA-Ku scaffold / Korea Institute of Oriental Medicine / DNA-PKcs complex / DNA-PK complex / Ewha Womans University / Michigan State University / College of Pharmacy / Korea Institute of Radiological / College of Dentistry Yonsei University / /

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serum-free media / cellular systems / In vitro translation products / molecular network / phosphorylation site / cell survival using other cell line systems / /

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MCF7 human breast cancer / human lung carcinoma / metastasis / CT26 colon carcinoma / aggressive tumor characteristics / hypersensitivity / lung metastases / human colorectal adenocarcinoma cells / tumor / human non-small cell carcinoma / Cancer DNA double-strand breaks / cancer / tumors / Disease / DNA-PKcs deficiency / human cancer / lung metastasis / aggressive tumor / tumor metastases / significantly inhibited lung metastasis / M059J/M069K human glioblastoma cells / CT26 murin colon carcinoma / /

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Michigan State University / College of Pharmacy / Herbal Medicine Research Division / Department of Oral Pathology / Korea Institute of Oriental Medicine / Yonsei University / Seoul / Korea Institute of Radiological / Division of Life and Pharmaceutical Sciences / Institutional Animal Care and Use Committee / Korea Institute of Radiological and Medical Sciences / Ewha Womans University / Seoul / /

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Prado Walnut / Katheryn Meek / /

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SC / TNT / dna - damage sensitivity / DNA repair activity / mutant / cells / /

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radiation / electrophoresis / SiRNA / Antibodies / Biotechnology / Cell Signaling Technology / recombination / gel electrophoresis / recombinant DNA / /

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www.nature.com/cddis / /

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