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Peptides / Neuroendocrinology / Lanreotide / Cell biology / Somatostatin / Cell culture / Neuroendocrine tumor / Critical micelle concentration / Biology / Medicine / Endocrine system


Article pubs.acs.org/molecularpharmaceutics A Novel Lanreotide-Encoded Micelle System Targets Paclitaxel to the Tumors with Overexpression of Somatostatin Receptors Nan Zheng,† Wenbing Dai,† Wenwen Du,† Haoran Zhan
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Document Date: 2014-12-05 00:44:25


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City

Dallas / Montreal / San Jose / St. Louis / Shanghai / Mannheim / Beijing / /

Company

Various Micelle Systems / Roche Diagnostics GmbH / State Key Laboratory / GL Biochem Ltd. / Molecular Probes Inc. (USA) / Varian Corporation / Haikou Pharmaceutical Co. Ltd. / Rigaku Corporation / Bristol-Myers Squibb Co. / Invitrogen Corp. / Biomimetic / lanreotide-PM-DiD / Thermo Nicolet Corporation / DiD / PM-DiD / Becton Dickinson / Biotium Inc. / Advanced Polymer Materials Inc. / /

Continent

America / /

Country

Japan / Canada / United Kingdom / China / Taiwan / Germany / United States / South Korea / /

Event

FDA Phase / /

Facility

State Key Laboratory of Natural / Vital Laboratory Animal Center / hospital of Beijing / Scale bar / UT Southwestern Medical Center / In clinic / Institute of Basic Medical Science / Peking University / Peking University Health Science Center / /

IndustryTerm

micelle systems / glucose solution / histochemical processing / antitumor drug delivery systems / active and passive / nitrogen gas / fluorescence imaging / imaging / aqueous solution / Micelle solution / food / micelle delivery systems / clear micelle solution / tumor site / final product / micellar systems / reaction product / drug delivery systems / phosphotungstic acid solution / micellar carrier / diagnostic imaging / mL micellar solutions / active targeting / vivo imaging / final solution / chemical interactions / cancer treatment / in vivo fluorescence imaging / ex vivo imaging / ex vivo fluorescence imaging / in vivo imaging system / aqueous media / long-circulating carrier / /

MedicalCondition

Relative tumor volume / H446 tumor / medullary thyroid carcinomas / each tumor / day/tumor / breast cancer / H446 tumors / tumor / H446 cancer / SSTR2-overexpressing tumors / SSTR2-overexpressing solid tumors / cancer / Tumors / small cell carcinomas / lymphomas / human neuroendocrine tumors / different cancer / enhanced tumor / endocrine pancreatic tumors / stronger tumor / Many tumor / hypersensitivity / harvested H446 tumors / SSTR overexpressing tumor / cancers / adenocarcinomas / pheochromocytomas / solid tumor / SSTR2-overexpressing tumor / SSTR2-positive tumor / high tumor / paragangliomas / pituitary adenomas / /

MedicalTreatment

drug delivery systems / dialysis / drug delivery system / /

MusicGroup

Blood / /

Organization

Institutional Animal Care and Use Committee / Harold C. Simmons Comprehensive Cancer Center / Vital Laboratory Animal Center / FDA / UT Southwestern Medical Center / NHS / School of Pharmaceutical Sciences / Peking University Health Science Center / Department of Pharmacology / Institute of Basic Medical Science / Peking University / Beijing / /

Person

Xuan Zhang / † Jinming / Nan Zheng / Taxol / Sakura Finetek / Hua Zhang / † Xueqing / Qiang Zhang / /

Position

Prime Minister / PTX-loaded PM / DiD-loaded PM / representative / C6loaded PM / blank PM / Genexol-PM / /

Product

cisplatin / Paclitaxel / glycine / RBC suspension / DTPA / penicillin / polyethylene glycol / isoflurane / LG 600G Cellular Phone / indocyanine green / EL / Taxol / C6 / micelle / containing paclitaxel / /

ProvinceOrState

Quebec / California / Texas / Hainan / /

Technology

radiation / X-ray / mPEG / apoptosis / drug delivery / drug delivery system / spectroscopy / dialysis / laser / diagnostic imaging / /

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