Structure-based medicinal chemistry towards subtype-selective kainate receptor ligands Tommy N. Johansen Medicinal Chemistry Research Why? The GluK2 and GluK3 kainate-type subunits are two out of more than

Source URL: drug.ku.dk

Phase 1b of WNT inhibitor ipafricept (IPA, decoy receptor for WNT ligands) with carboplatin (C) and paclitaxel (P) in patients (pts) with recurrent platinum-sensitive ovarian cancer (OC) Roisin O’Cearbhaill1, Scott McM

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Article pubs.acs.org/jmc Fragment-Based Design of Selective Nanomolar Ligands of the CREBBP Bromodomain Andrea Unzue,† Min Xu,‡ Jing Dong,‡ Lars Wiedmer,‡ Dimitrios Spiliotopoulos,‡ Amedeo Caflisch,*,‡

Source URL: www.biochem-caflisch.uzh.ch

Neuropharmacological investigations of GABAA/C receptors and ligands. Background GABA is the most important inhibitory neurotransmitter in the central nervous system, and disorders of the GABAergic neurotransmission are

Source URL: drug.ku.dk

Design and synthesis of ligands for studying the GABAA or nicotinic acetylcholine receptors The GABAA and nicotinic acetylcholine (nACh) receptors, which are structural very similar, are both important drug targets in a

Source URL: drug.ku.dk

letters to nature hypothesis because it indicates that the parental magma is not particularly evolved. There are two observations that are inconsistent with the hypothesis that KREEP initiates melting of mafic cumulates

Source URL: www.biocenter.helsinki.fi

• Human mouth anatomy
• Cell biology
• Biology
• Human body
• Cell signaling
• Ligands
• Morphogens
• Proteins
• Sonic hedgehog
• Cusp
• Human tooth development
• Molar

Published on WebA New Copper Acetate-Bis(oxazoline)-Catalyzed, Enantioselective Henry Reaction David A. Evans,* Daniel Seidel, Magnus Rueping, Hon Wai Lam, Jared T. Shaw, and C. Wade Downey

Source URL: evans.rc.fas.harvard.edu

• Chemistry
• Coordination chemistry
• Organic reactions
• Nitroaldol reaction
• Chemical reaction
• Bisoxazoline ligand
• Ligand
• Josiphos ligands
• Dynamic kinetic resolution in asymmetric synthesis

Aggregated α-synuclein intoxication of primary dopaminergic neurons as an in vitro model of Parkinson diseaseD. Buttigieg ; E. Gras-Lavigne ; M. Ouamer ; R. Steinschneider

Source URL: www.neuronexperts.com

• Neurotrophic factors
• Neurotoxins
• Pyridines
• Neurological disorders
• Peripheral membrane proteins
• Neurturin
• Neurodegeneration
• Alpha-synuclein
• GDNF family of ligands
• Glial cell line-derived neurotrophic factor
• Brain-derived neurotrophic factor
• Neuron

Monoamine ligands binding to the dopamine, norepinephrine and serotonin transporters :

Source URL: infochim.u-strasbg.fr

BRENDA Tutorial Ligand Search How to find ligands / metabolites such as substrates, products, inhibitors etc.

Source URL: www.brenda-enzymes.org