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Proteins / Cell signaling / Protein kinases / Protein kinase A / AKAP / G protein-coupled receptor / Phosphorylation / Protein kinase / Membrane transport / Biology / Cell biology / Signal transduction


Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes Jeffrey J. Saucerman*, Jin Zhang†, Jody C. Martin*, Lili X. Peng*, Antine E. Stenbit‡, Roger Y. Tsien§¶储, and Andrew D. McCulloc
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Document Date: 2014-07-01 03:40:01


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File Size: 1,38 MB

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Santa Fe / Seattle / Tucson / Baltimore / Novato / DAKAR / Tokyo / La Jolla / Louis / Ashland / Downington / Indianapolis / Manheim / Lincoln / Shenoy / St. Louis / /

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Nikon / Universal Imaging Corporation / Roche Diagnostics / MatTek Corp. / Belevych A. E. / /

Country

Japan / United States / /

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Event

Movie Release / /

Facility

PKA-bound cAMP / cAMP Saucerman et al. / Howard Hughes Medical Institute / Buffered cAMP / Scale bar / cAMP accumulation兾degradation / Whitaker Institute of Biomedical Engineering / cAMP兾PKA / PDE scaffolding / M DMNB-caged cAMP / DMNB-caged cAMP / University of Washington School / University of California / /

IndustryTerm

live-cell imaging / saline solution / real-time fluorescence imaging / treatment of heart failure / Recent live-cell imaging / local uncaging site / fluorescence imaging / cell-signaling networks / imaging / activation site / online use / live-cell imaging data / numerical solution / /

Movie

A. D. / Conflict of interest / A.D. / /

Organization

Johns Hopkins School of Medicine / National Science Foundation / University of Washington School of Medicine / National Academy of Sciences / University of California at San Diego / Department of Bioengineering / Whitaker Institute of Biomedical Engineering / Howard Hughes Medical Institute / /

Person

Andrew D. McCulloch / Jody C. Martin / Laurence Brunton / Jin Zhang / Nat / Scott / Kirk Knowlton / Roger Y. Tsien / Jeffrey J. Saucerman / Lili X. Peng / Corbin / Joseph A. Beavo / /

Position

A-kinase activity reporter / MP / FRET reporter / Representative / /

Product

M-16 / /

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Maryland / Washington / S. K. / Scarborough / California / /

Technology

Neuroscience / html / apoptosis / simulation / /

URL

www.nrcam.uchc.edu / www.pnas.org兾cgi兾doi兾10.1073兾pnas.0600137103 / /

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