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City Ann Arbor / Nurnberg / Paris / Stockholm / London / New York / / Company Harding AE / Thieme Medical Publishers Inc. / / Country Tunisia / United States / / Currency pence / / Facility Ann Arbor Veterans Affairs Medical Center / University of Michigan / University School / / IndustryTerm careful search / / MedicalCondition inherited disorder / alternative disorders / lower extremity paresthesia / hydrocephalus / slowly progressive motor neuron disease / dysarthria / aphasia / Dementia / seizures / adrenomyeloneuropathy / Spastic and syphilitic spinal paralysis / ALS / autosomal recessive spastic paraplegia / PLS a sporadic disorder / gastroesophageal reflux / sporadic disorder / amyotrophic lateral sclerosis / infantile and early childhood onset lower extremity spastic weakness / diagnosable disorders / insidiously progressive spastic weakness / HEREDITARY SPASTIC PARAPLEGIA Hereditary / Garg N. Familial spastic paraplegia / disorder / refined familial spastic paraplegia / insidiously progressive spastic paraparesis / neurologic deficits / autosomal dominant hereditary spastic paraplegia / idiopathic spastic paraparesis / associated gaze paresis / progressive spastic paraplegia / slowly progressive spastic weakness / senile dementia / pure hereditary spastic paraplegia / steadily progressive multiple sclerosis / spinal cord disease / Hereditary (familial) spastic paraplegia / Troyer syndrome / Kjellin syndrome / nongenetic disorders / extensor plantar responses / mental retardation / Hereditary / paraplegia / painful leg cramps / hyperreflexia / autosomal dominant familial spastic paraplegia / hereditary disorder / Silver syndrome / shuffling gait / complicated paraplegia / dysphagia / Lateral Sclerosis John K. Fink / motor system disorder / cognitive impairment / hereditary ascending spastic paralysis / Berciano J. Hereditary / pathologic lower extremity hyperreflexia / onset spastic paraparesis / extensor plantar response / relatively nonprogressive disorders / X-linked spastic paraplegia / undoubtedly heterogeneous disorders / insidiously progressive spastic paraplegia / autosomal recessive hereditary spastic paraplegia / paraplegias / hereditary cerebellar ataxia / disuse atrophy / hypotonia / hereditary spastic paraparesis / familial spasmodic paraplegia / spastic paraplegia syndrome / Such disorders / autosomal dominant spastic paraplegia / McKusick VA. The Troyer syndrome / disorders / dysphagia / optic disk pallor / Strümpell’s disease / spinocerebellar ataxia / pathologic hyperreflexia / separate disorder / Pure spastic paralysis / X-linked disorder / neurologic signs / Krabbe disease / Saturen P. Familial spastic paraplegia / MASA syndrome / diverse disorders / Hereditary Spastic Paraplegia / complicated familial spastic paraplegia / dominant familial spastic paraplegia / seemingly disparate disorders / corticobulbar muscle weakness / inherited syndrome / peripheral neuropathy / progressive spastic weakness / motor neuron disorders / spastic weakness / late-onset globoid cell leukodystrophy / inherited disorders / heterogeneous disorders / Gambi D. Strümpell’s familial spastic paraplegia / dominant hereditary spastic paraparesis / progressive lower extremity spastic weakness / Subclinical cognitive impairment / demyelination / motor neuron disease / primary lateral sclerosis / muscle atrophy / Apparently sporadic spastic paraplegia / Al-Sharkawy S. Troyer Syndrome / Progressive Spastic Paraparesis / lower extremity spastic weakness / etiologically distinct disorders / Malcolm S. PelizaeusMerzbacher disease / spastic paraparesis / spinal muscular atrophy / cataracts / disease / familial spastic paraplegia / subtle deficiency / spastic paraplegia / Familial childhood primary lateral sclerosis / PROGRESSIVE SPASTIC PARAPARESIS/FINK / hereditary ataxias / Hereditary spastic paraplegias / autosomal dominant pure spastic paraplegia / recessive familial spastic paraplegia / Friedreich’s ataxia and familial spastic paraplegia / unilateral hyperreflexia / Hedera P. Hereditary spastic paraplegia / syndrome showing bilateral cataracts / related disorders / Pelizaeus-Merzbacher disease / recessive spastic paraplegia / allelic disorders / genetically distinct disorders / central retinal degeneration / etiologically heterogeneous disorders / clinically definite amyotrophic lateral sclerosis / syndrome / fasciculations / separate disorders / senile-onset dementia / / NaturalFeature Rogers MT / / Organization University of Michigan / Indiana University School of Medicine / Ann Arbor Veterans Affairs Medical Center / Hernandez A. Association / Accreditation Council for Continuing Medical Education / AD HSP / Geriatric Research Education and Care Center / / Person Ann Neurol / Maia M. Strümpell / Fink / Al-Sharkawy S. Troyer / Arch Neurol / Ann Hum / Arch Phys Med / Patterson V / Gene Flanking Markers References Spastin / Silver JR. / / / Position physician / author / Fisher / / ProvinceOrState Michigan / New York / / PublishedMedium the Veterans Affairs Merit Review / / RadioStation Dearlove AM / Slavotinek AM / / Technology magnetic resonance imaging / genotype / cloning / / SocialTag 
Progressive Spastic Paraparesis: Hereditary Spastic Paraplegia and Its Relation to Primary and Amyotrophic Lateral Sclerosis John K. Fink, M.D.1 ABSTRACT