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Microbiology / Pertussis / Bordetella pertussis / Bordetella / Vaccine / Rhesus macaque / Haemophilus influenzae / Bordetella parapertussis / Bacteria / Burkholderiales / Biology


Nonhuman Primate and Human Challenge Models of Pertussis Tod J. Merkel, PhD1 and Scott A. Halperin, MD2,3,4 1 Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food a
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City

Halifax / Cotter / Bethesda / /

Company

Oxford University Press / GlaxoSmithKline / Sanofi / Halperin SA / /

Country

Guinea / United States / /

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Facility

Dalhousie University / Laboratory of Respiratory / /

IndustryTerm

healthcare professionals / healthcare professional / /

MedicalCondition

primate infection / human clinical pertussis / B. pertussis infection / DF / Whooping cough / prolonged cough illness / Pertussis Tod J. Merkel / next-generation pertussis / significant leukocytosis / typical infection / Severe pertussis / severe cough / serious infections / Notifiable diseases / leukocytosis / natural B. pertussis infection / pertussis infection / highly contagious / acute respiratory illness / only mild infections / severe respiratory distress / Pertussis Tod J. Merkel1 / peak leukocytosis / paroxysmal coughing / Hambrecht L. Experimental whooping cough / severe disease / infections / pneumonia / coughs / human pertussis / Bordetella pertussis / cough illness / Pulmonary infections / disease / paroxysmal coughs / vaccine-preventable disease / pertussis / B. pertussis / pertussis disease / coughing / Anderson G. Experimental pertussis / natural B. pertussis infections / Bordetella pertussis infection / peak illness / diseases / typical whooping cough / Canada Despite pertussis / infectious diseases / infection / mild pertussis / cough / McIntyre P. Pertussis / mild cough / Infectious disease / bacterial pathogen Bordetella pertussis / Experimental whooping cough / /

MedicalTreatment

antibiotics / vaccination / /

Organization

Accreditation Council for Continuing Medical Education / Food and Drug Administration / US Government / National Foundation for Infectious Diseases / Infectious Diseases Society of America / 2Canadian Center for Vaccinology and 3Department of Pediatrics and 4Department of Microbiology and Immunology / Division of Bacterial / Parasitic and Allergenic Products / Centers for Disease Control and Prevention / National Foundation for Infectious Diseases SUPPLEMENT ARTICLE Nonhuman Primate / Oxford University / Dalhousie University / Center for Biologics Evaluation and Research / Laboratory of Respiratory and Special Pathogens / /

Person

Theresa Finn / Nicholas Carbonetti / Drusilla Burns / Scott A. Halperin / Tod J. Merkel / /

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Position

advisor / Chen PM / author / /

ProvinceOrState

Maryland / Pennsylvania / /

PublishedMedium

The Journal of Infectious Diseases / /

Technology

antibodies / /

URL

http /

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