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City Irvine / Mandeville / / Company Current Medicine Group LLC / Sigma-Tau Pharmaceuticals / Spectrum Pharmaceuticals / / Country United States / / Currency USD / / / Event Product Issues / FDA Phase / / Facility Cleveland Clinic / / IndustryTerm high energy demands / energy shuttle / energy production / high-energy phosphates / respiratory chain / energy fuels / mitochondrial disease therapy / Treatment of Mitochondrial Disease / chemical / / MedicalCondition fatty acid oxidation disorders / intractable seizures / headache / myopathy / liver dysfunction / II disease / dysfunction / neonatal encephalopathy / medically refractory epilepsy / nausea / CSF deficiency / gastroesophageal reflux / mitochondrial disorders / reduced tissue injury / treatable mitochondrial diseases / Peripheral neuropathy / primary mitochondrial disorders / hyponatremia / Primary carnitine deficiency / starvation / Acute stroke / palatable chronic use / Kearns-Sayre syndrome / diarrhea / Hypersensitivity / Mitochondrial diseases / platinum Hearing loss / secondary cerebral folate deficiency / illness / Hearing loss / hepatic disease / Hypotension / mitochondrial encephalomyopathy / responsive epilepsy / metabolic and mitochondrial diseases / mitochondrial dysfunction / Tachyarrhythmia / MELAS / hemolytic anemia / lipodystrophy / pyruvate dehydrogenase deficiency / disease / metabolic diseases / human mitochondrial disease / cerebral folate deficiency / mitochondrial disease / mitochondrial encephalomyopathies / minor illness / meals Monitoring Acute stroke / amino Acute stroke / extreme malnutrition / fever / certain mitochondrial disorders / Leigh syndrome / vomiting / renal insufficiency / acyl CoA dehydrogenase deficiency / lactic acidosis / rare disorders / mitochondrial myopathies / metabolic strokes / extrapontine myelinolysis / Allergic reactions / every mitochondrial disease / very long chain acyl CoA dehydrogenase deficiency / recessive ataxia / infectious diseases / pyruvate carboxylase deficiency / human Mitochondrial Disease disease / dose-dependent and exposure-dependent reversible peripheral neuropathy / infection / carnitine deficiency / deficiency / secondary fatty acid oxidation disorders / Rash / disorders / dehydration / / MedicalTreatment enteral feeding / salvage therapies / Immunizations / antibiotics / surgery / / Organization Chronic administration / CoQ10 administration / MADD / Mitochondrial Medicine Society / US Food and Drug Administration / / Person Sumit Parikh / Richard Haas / DO / Russell Saneto / / Position Corresponding author / advocate / / Product Aminoglycoside / Acetaminophen / Dextrose / menadione / metronidazole / folic acid / Valproic acid / adenosine / Carnitor / platinum Hearing loss / DCA / carnitine synthesis / chemotherapeutics / cardiac toxicity / CoQ10 / mtDNA translation Aminoglycoside / / Technology Alpha / research protocols / apoptosis / Pharmacokinetics / genotype / / URL http / SocialTag 
A Modern Approach to the Treatment of Mitochondrial Disease Sumit Parikh, MD Russell Saneto, DO, PhD Marni J. Falk, MD Irina Anselm, MD