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Apoptosis / Genetic engineering / Mitochondrial biogenesis / Immune system / Cell signaling / Mitochondrion / Autophagy / SIRT3 / PPARGC1A / Biology / Cell biology / Programmed cell death


Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity: dual roles for ERK1/2
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Document Date: 2012-05-24 05:56:25


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Kodak / Thermo Fisher / Millipore / Olympus America Inc. / mCi / Creative Commons / Jackson Immuno-Research Laboratories / PerkinElmer / Macmillan Publishers Limited / /

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United States / United Kingdom / /

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pence / /

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Product Issues / /

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Marshall University / In stable / University of Pittsburgh / University of Pittsburgh School / Pennsylvania State University / McGowan Institute / University Park / University of Pittsburgh Cancer Institute / /

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mtDNA-encoded translation products / reticular mitochondrial network / live-cell and live-animal bioluminescent imaging / repeated low-dose applications / Energy substrate / acute and chronic systems / mitochondrial translation products / /

MedicalCondition

acute injury / chronic intoxication / mitochondrial injury / dementia / Neuroscience Mitochondrial dysfunction / neurodegenerative disease / autophagy-lysosomal dysfunction / chronic mitochondrial stress / chronic low-dose injury / chronic model / chronic low-dose toxicity setting / colon cancer / injury / microtubule dysfunction / chronic parkinsonian neuronal injury / parkinsonian injury / MS / chronic / low-dose exposures / chronic exposures / chronic setting / acute and chronic systems / Parkinson-like syndrome / mitochondrial dysfunction / necrosis / cancer / Disease / Repeated mild brain injuries / chronic dopaminergic glutathione depletion / cognitive impairment / diabetes / neuroblastoma cells / chronic administration / significant mitochondrial injury / Parkinson’s disease / Progressive parkinsonism / Chronic MPP / elicited dissociation / neurodegenerative diseases / Lewy body diseases / injuries / /

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Repeated administration / University of Pittsburgh Cancer Institute / National Institute of Health / Department of Pathology / Pennsylvania State University / 5The McGowan Institute for Regenerative Medicine / Marshall University / University of Pittsburgh / Pittsburgh / University of Pittsburgh School of Medicine / Center for Neuroscience / 3The Department of Pharmacology and Chemical Biology / Division of Neuropathology / /

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Kerby J. Retinoic / Xia Z. Loss / Alexa Fluor / Kim SR / Peroxisome / Microbiology / /

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*Corresponding author / post-hoc Fisher / Representative / Suliman HB / /

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mitochondrial biogenesis / degradation / mitochondria / /

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ML / /

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West Virginia / Oregon / Pennsylvania / Georgia / /

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PLoS ONE / Molecular Biology / /

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Cuervo AM / /

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alpha / Neuroscience / AV / electrophoresis / antibodies / siRNA / Biotechnology / Cell Signaling / OCR / gene expression / PDH / Regenerative Medicine / /

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