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Quaternary ammonium compounds / Nicotinic agonists / Pyridines / G protein coupled receptors / Acetylcholine / Epibatidine / Acetylcholine receptor / Muscarinic antagonist / Hexamethonium / Chemistry / Biology / Biochemistry


Antinociceptive effect of spirocyclopiperazinium salt compound LXM-15 via activating peripheral α7 nAChR and M4 mAChR in mice
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Document Date: 2014-12-05 00:43:28


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City

Santos / Boston / LXM / Tokyo / Neuroreport / Lin / Rupniak / Sauer / St. Louis / Maidstone / /

Company

Sigma Chemical Co. / American Radiolabeled Chemicals Inc. / Whatman Intl. Ltd. / Nihon Konden Corp / Biomimetic / Russell / Basile A.S. / Potter B.V. / Tran L.P. / Beijing Applygen Technologies Inc. / Ó 2010 Elsevier Ltd. / Arneric S.P. / Mohamad A.S. / PerkinElmer / /

Country

United States / United Kingdom / China / /

/

Event

FDA Phase / /

Facility

Institute of Materia Medica / Nanjing Jiancheng Bioengineering Institute / Laboratory Animal Science / Neuroscience Research Institute of Peking University / Peking University / /

IndustryTerm

chemical structure / persistent chemical pain stimuli / /

MedicalCondition

hyperalgesia / tremor / bradycardia / ataxia / incoordination / hypothermia / pain / /

MedicalTreatment

pain management / /

Organization

Institute of Materia Medica / School of Pharmaceutical Sciences / International Association for the Study of Pain / National Science Foundation / Medical and Healthy Analysis Center / Institutional Animal Care and Use Committee / PR China Department of Molecular and Cellular Pharmacology / Neuroscience Research Institute / National Academy of Sciences / Peking University / Beijing / State Key Laboratory of Natural / Department of Chemical Biology / Nanjing Jiancheng Bioengineering Institute / Department of Laboratory Animal Science / s.c. administration / Chinese Academy of Medical Sciences / Department of Molecular and Cellular Pharmacology / /

Person

Holladay / Hardick / Gerber / Kim / Sotnikova / Yan Song / Xia Zhao / Blagbrough / Gainetdinov / Jia Ye / /

/

Position

T.D. / D.J. / Corresponding author / /

Product

acetaminophen / pentobarbital sodium / naloxone hydrochloride / tropicamide / Diazepam / naloxone / M-16 / gabapentin / acetic acid / atropine / A-85380 / nicotine / LXM-15 / /

ProvinceOrState

S.K. / New Mexico / New Hampshire / /

PublishedMedium

Proceedings of the National Academy of Sciences / Journal of Neuroscience / /

SportsLeague

International Association / /

Technology

alpha / Neuroscience / Drug Development / /

URL

www.elsevier.com/locate/neuropharm / /

SocialTag