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Stem cells / Cerebrum / Subgranular zone / Subventricular zone / Neural stem cell / Biotechnology / Notch-2 / Nestin / Notch signaling pathway / Biology / Neuroanatomy / Developmental biology


Constitutive Notch2 signaling in neural stem cells promotes tumorigenic features and astroglial lineage entry
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City

Glostrup / Newmarket / Abingdon / Wallisellen / Boston / Iowa City / Kornblum / Cambridge / Zug / Basel / St. Louis / Santa Cruz / Newcastle / /

Company

NSCs / Studies Hybridoma Bank / GE / Genentech / Affymetrix / Creative Commons / Macmillan Publishers Limited / /

Country

Switzerland / Germany / United States / United Kingdom / Denmark / /

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Facility

Planck Institute / University of Basel / Scale bar / Rictor complex / Institute of Physiology / University Hospital Basel / University of Saarland / NSCs shed / Miescher Institute / /

IndustryTerm

neurosphere media / Data-mining / protease cleavage-site / proteolytic processing / /

MedicalCondition

oligodendroglioma and low Notch2 levels / malignant astrocytomas / glioma stem cells / glioma cells / glioma stem cell / CD133-positive glioblastoma cells / Glioma / pre-T acute lymphoblastic leukemia / GBM patient tumor / J Cancer / mixed oligodendroglioma / gliomas / astrocytomas / Neuroscience Gliomas / oligodendrogliomas / morphologically distinct astrocytomas / astrocytoma formation / T-cell acute lymphoblastic leukemia / Malignant astrocytic glioma / highly malignant astrocytoma / MS / recurrent high-grade glioma / Brain tumour / PTEN tumor / glioblastoma / primary tumors / Human cortical glial tumors / tumor / particular glioma / adenomas / cancer / tumors / human glioma cell lines / Disease / human glial brain tumors / glioblastoma multiforme / oligodendroglioma / PFA / lung adenocarcinoma cells / malignant gliomas / astrocytoma / tumours / /

MedicalTreatment

chemotherapy / /

NaturalFeature

Lake RJ / /

Organization

University of Basel / National Institute of Health / World Health Organization / Institute of Physiology / 3Friedrich Miescher Institute for Biomedical Research / 4Max-Planck Institute for Experimental Medicine / Intraperitoneal administration / Department of Biomedicine / University of Saarland / /

Person

Lewis J. Neurogenic / Aster / Taylor V / P. Notch / /

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Position

Genedata Analyst / Switzerland *Corresponding author / reporter / /

Product

carboplatin / Sigma / etoposide / HMS / /

ProvinceOrState

Maryland / South Dakota / Saarland / /

PublishedMedium

PLoS One / /

RadioStation

Vaccarino FM / /

Technology

Adam / Neuroscience / bioinformatics / antibodies / Cell Signaling / Genotyping / stem cells / DSL / apoptosis / DNA Chip / Gene expression / chemotherapy / Neurosurgery / genotype / recombination / /

URL

http /

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