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Neurochemistry / Neurodegeneration / Heritability of autism / Endoplasmic-reticulum-associated protein degradation / Unfolded protein response / Neuron / Endoplasmic reticulum / Signal transduction / Neurexin / Biology / Cell biology / Neuroscience


Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule, CADM1
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Document Date: 2010-06-03 05:58:27

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National Institute of Mental Health / Jichi Medical University / The University of Tokyo / International University of Health / National Institute of Neuroscience / /

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protein processing / chemical chaperone activity / automated protein homology-modeling server / potential chemical chaperone / chemical structure / Chemical chaperones / /

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Neuroscience Autism spectrum disorder / Autism spectrum disorder / Bombardieri R. Tuberous sclerosis / monogenic heritable autism / tuberous sclerosis / MS / Momoi T. Conformational diseases / common heritable neurodevelopmental disorder / autism spectrum disorders / tumor / synaptic density protein/Drosophila disc large tumor / Fujita E. Heritable neurodevelopmental disorders / mental retardation / Disease / human lung cancer / emphysema / autism / tuberous sclerosis complex / Chronic and excess ER stress leads / nervous and mental disorders / neurogenetic disorder / epilepsy / deficiency / liver injury / neurodevelopmental disorder / /

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Jichi Medical University / Japan Health Science Foundation / National Institute of Neuroscience / MIT / Japanese Ministry of Education / University of Tokyo / Division of Differentiation and Development / Graduate School / Center for Medical Science / Ministry of Health / International University of Health and Welfare / National Institute of Mental Health / /

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Clara M Lajonchere / Alaa El-Husseini / Alexa Fluor / Ron D. Translational / Interaction / /

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Japan *Corresponding author / Cao / Banker / /

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Sigma / hetz / trafficking / social interaction / mice26 / synaptic function / mouse embryos / nlgn3-deficient mice6 / the pathogenesis / mice / social behavior.12 / 13 This finding / ultrasonic vocalization / mice embryos / synaptogenesis / /

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British Columbia / Victoria / Massachusetts / /

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alpha / Neuroscience / antibodies / Cell Signaling Technology / laser / spectroscopy / http / viewed using a confocal laser-scanning microscope / /

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