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Mental processes / Cognitive science / Neurofibroma / Genodermatoses / Neurofibromin 1 / NF1 / Memory / GTPase / Working memory / Mind / Biology / Neuroscience


Cell Reports Report Modulation of cAMP and Ras Signaling Pathways Improves Distinct Behavioral Deficits in a Zebrafish Model of Neurofibromatosis Type 1
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Document Date: 2014-09-12 09:58:40

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City

Nurnberg / New York / P. / Zhong / Federov / /

Company

Fleming / James A.S. / Sigma-Aldrich / Bain / Mutant Larvae Exhibit Reduced Memory / Kushner S.A. / J.A.E. / E.D.d. / /

Country

United States / /

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Event

Product Issues / Product Recall / /

Facility

Teachers College / BIOLOG Life Science Institute / Columbia University / cAMP Signaling Mediates / University of Pennsylvania Institutional Animal Care / University of Pennsylvania / Enhancing cAMP / University of Wisconsin / /

IndustryTerm

corticostriatal inhibitory networks / larval media / therapeutics for neuropsychiatric disorders / treatment of cognitive dysfunction / animal protocols / Chemical modulation / /

MedicalCondition

memory deficit / memory dysfunction / attention-deficit-hyperactivity disorder / 2Department SUMMARY Neurofibromatosis / Mody / Dopamine deficiency / learning disabilities / Drosophila neurofibromatosis / neuropsychiatric disorders / Zebrafish neurofibromatosis / dramatic memory deficits / Cancer / benign and malignant tumors / INTRODUCTION Neurofibromatosis / cognitive impairment / common autosomal-dominant disorder / neurofibromatosis / cognitive dysfunction / memory deficits / NF1 tumor / growth deficiency / Heat shock / dehydration / /

OperatingSystem

ISIs / /

Organization

Columbia University / National Institute of Health / Teachers College / Department of Zoology / Perelman School of Medicine / the University of Pennsylvania / University of Pennsylvania Institutional Animal Care and Use Committee / BIOLOG Life Science Institute / University of Pennsylvania / Philadelphia / University of Wisconsin / Madison / Department of Defense / FRAXA Research Foundation / /

Person

Neurol / Davis / Silva / Tom Look / Jayachandran / Kurt Marsden / Squire / Cannon / Arthur Shores / Hariharan / Kurt Engleka / Min Min Lu / Van Vactor / /

Position

Walker / 3Co-first author / T.D. / Plater / author / /

Product

memory / lovastatin / cAMP generation / memory deficits / zebrafish exhibit learning / neurofibromin function / /

ProvinceOrState

Wisconsin / New Brunswick / British Columbia / Pennsylvania / /

PublishedMedium

PLoS ONE / /

Technology

genotyping / Cell Signaling Technology / genotype / animal protocols / flash / /

URL

http /

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