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Neurotransmitter transporters / Membrane biology / Neurotransmitters / Drug discovery / Medicinal chemistry / Reuptake / Norepinephrine transporter / Monoamine transporter / Norepinephrine / Biology / Chemistry / Biochemistry


Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET Avner Schlessingera,b,c,1, Ethan Geiera, Hao Fana,b,c, John J. Irwinb,c, Brian K. Shoichetb,c, Kathleen M. Giacominia
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Document Date: 2013-10-15 11:56:53

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Chichester / Kuntz / New York / San Carlos / /

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IBM / Protein Data Bank / Hewlett Packard / NET / Phe317 / DrugBank / Ligand / Phe72 / Tyr152 / Intel / Asp75 / Ser419 / John Wiley & Sons / /

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Europe / /

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Uruguay / Poland / Japan / United States / Brazil / Portugal / United Kingdom / China / Greece / /

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pence / /

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Columbia University / NET stable / Hughes Medical Institute / University of California / cCalifornia Institute / /

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tuaminoheptane heptane / chemical libraries / chemical similarity / charged amine / norephedrine amine / peripheral and central nervous systems / side chain / modeled binding site / amine / affinity substrate site / treatment of Alzheimer’s disease / treatment of various disorders / chemical similarity ensemble approach / allosteric site / hydroxyl / adrenergic and cholinergic systems / clomipramine-binding site / polar / /

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Columbia University / Department of Bioengineering and Therapeutic Sciences / Pharmaceutical Chemistry / and cCalifornia Institute for Quantitative Biosciences / Center for Structures of Membrane Proteins / Hughes Medical Institute / University of California / San Francisco / SLC6 / /

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Mike Homer / John J. Irwinb / Ethan Geiera / Chem Commun / Andrej Salia / Kathleen M. Giacominia / Elina Tjioe / Ursula Pieper / Sook Wah Yee / Ben Webb / Hao Fana / Ron Conway / Amber Dahlin / Keren Lasker / Brian K. Shoichetb / /

Position

allosteric model for membrane pumps / Author / /

Product

Venlafaxine / Effexor / penicillin / MODELLER-10v8 / mercaptopurine / Atomoxetine / balanced salt / clozapine / epinephrine / Strattera / Lamivudine / Nicotine / Ritalin / WAL / /

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alpha / Genomics / Molecular modeling / X-ray / cloning / html / chemical libraries / drug discovery / structural genomics / Decoys protocol / drug design / drug development / /

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