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City Nicosia / Preston / Pittsburgh / / Company Perera L. P. / / Country United States / / / Event Product Issues / / Facility E1240 Biomedical Science Tower / University of Pittsburgh School / / / IndustryTerm animal model systems / cancer therapy / encephalomyocarditis virus internal ribosome entry site / potential applications / nervous system applications / e - l / fertile site / immediate early gene products / ectopic site / treatment of neurodegenerative disease / gC ectopic site / amplification systems / / MedicalCondition HIV / glioma cells / neurodegenerative disease / neurologic disease / Infectious virions / peripheral nervous system disease / natural infection / herpes / cold sores / experimental brain tumors / Infectious viral particles / Multiple sclerosis / brain tumors / human brain tumors / associated sensory ganglion / tumor / keratitis / human malignant glioma / Alzheimer’s disease / cancer / tumors / disease / Replication defective herpes simplex virus / trophic factor deficiency / Moloney murine leukemia virus / genetically engineered herpes simplex viruses / direct infection / e.g. tumor / initial infection / virus infection / e.g. tumor necrosis / latent infection / tumor killing inflammatory cells / sensory ganglion / Parkinson’s disease / diseases / chronic neurodegenerative conditions / scid / infection / Herpes simplex virus / characteristic cold sores / metastases / herpetic keratitis / infectious particles / / MedicalTreatment cancer therapy / Gene Therapy / / OperatingSystem MacIntosh / / Organization Department of Neurology / Department of Molecular Genetics and Biochemistry / University of Pittsburgh School of Medicine / / Person David J / Joseph C. Glorioso / Gene Ther / Reagan / / / Position Carpenter / Corresponding Author / Major / reporter / / Product ganciclovir / mutant viruses / mutants / Gene Therapy / Molecular Biology Vol / HSV / virus mutants / full-length HSV-based vectors / herpes simplex virus / helper virus / / ProvinceOrState Pennsylvania / / Technology alpha / AV / transplantation / stem cells / DNA binding / Gene Therapy / DNA synthesis / gene expression / treating cancer / gene delivery / / SocialTag 
Gene Therapy and Molecular Biology Vol 1, page 215 Gene Ther Mol Biol Vol 1, March, 1998. Gene transfer to the nervous system using HSV vectors M. Karina Soares1, William H. Goins1, Joseph C. Glorioso1,2,3, and