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City Carlsbad / Tokyo / San Jose / St. Louis / Burlingame / Rockville / Valencia / Cambridge / Oberkochen / Danvers / Alexandria / Foster City / Germantown / New Haven / / Company Vector Laboratories / Qiagen / NCr / BD Biosciences / ABC / Adobe Systems / Olympus / / Country Japan / Germany / United States / / Currency USD / / / Event Product Issues / FDA Phase / / Facility Scale bar / Ohio State University / Princeton University / Yale University / / IndustryTerm software version / imaging / brain systems / food / identical virus injection protocol / live real-time imaging / conventional treatment technologies / simultaneous imaging / injection site / laser time-lapse imaging / fluorescent imaging / Time-lapse confocal laser imaging / in vivo brain imaging / time-lapse in situ human brain tumor imaging model / Time-lapse confocal imaging / / MedicalCondition intracranial tumor / subcutaneous tumor grafts / human breast carcinoma / intact subcutaneous flank tumor / large infiltrative gliomas / primary high-grade gliomas / largest tumor / incidental tumor / mammary cancer / 4T1 mouse mammary carcinoma / fluorescence microscopy Introduction Cancer / disseminated systemic cancer / main tumor / viral infection / glioma cells / glioblastoma cells / deadliest diseases / VSV Targets Brain Cancer / seizures / glioma xenografts / high-grade human glioma / measles / rU118 high-grade glioma cells / tumor DsRed intensity deof tumor / rU87 tumors / dispersed tumor / bilateral striatal tumors / brain metastasis / systemic disease / Brain cancers / needle injury / neous oncolytic infection / SCID rU87 tumors / injury / rU118 tumors / selective viral infection / subcutaneous flank tumors / olfactory tumor / tuand rU87 tumors / BT474 human breast carcinoma / brain tumor / SCID mouse brain tumor / brain tumors / glioblastoma / systemic cancer metastasis / additional tumor / subcutaneous glioma model / tumor / kills migrating tumor / intracellular tumor / rU118 human glioblastoma xenografts / large tumors / cancer / tumors / brain metastases / striatal rU87 glioma xenografts / incuof VSV infection / VSV Targets Brain Cancer Results Tumor / mouse tumors / single infiltrating red tumor / Infected tumors / widespread selective infection / glioblastomas / tumor cell death VSV infection / recombinant pseudorabies virus / human cancer / olfactory bulb tumors / Metastatic Carcinoma / glioma types / malignant disease / peripheral metastases / Disease Systemic Vesicular Stomatitis Virus Selectively Destroys Multifocal Glioma / pseudorabies virus / both SCID / infiltrative tumors / formed brain tumors / red glioma cells / whole tumor / cosal infection / nerve tumors / infection / VSV Targets Brain Cancer protein / red tumor / Metastases / different cancer / vesicular stomatitis virus / human glioma / widely metastatic cancers / human glioblastoma / additional human carcinoma / lung carcinoma / peripheral sentinel tumors / U87MG human high-grade glioma cells / pseudorabies / PDGF mammary carcinoma / multifocal tumors / al- VSV infection / common brain cancer / recombinant herpes / much infection / human lung carcinoma cell lines / coronal brain slice tumor / metastasis / intractable epilepsy / genetically distinct human cancer / both systemic cancers / same tumor / glioma / VSV Targets Brain Cancer infection / nude mice SCID / 4T1 mouse mammary cancer / Disrupted tumor / herpes / Uninfected tumor / entire tumor / dead tumor / gliomas / mammary cancers / cortical glioma xenografts To / viral progeny target minute tumor / ANOVA an SCID / primary cancer / Sterile needle injury / rU87 glioma cells / glioblastoma and mammary tumors / whole tumor mass / systemic cancer / viable tumor / viral tumor / different brain tumor / Primary human glioblastoma cultures / resected glioblastoma surgery / same rU87 glioma xenograft / fluorescent tumor / lyse glioma cells / breast carcinoma / lung cancers / human gliomas / mouse mammary carcinoma / cancers / U118MG glioma cells / breast cancers / VSV tumor / VSV-infected tumor / glial tumor / individual infiltrative tumor / disease / single intrabrain tumors / control contralateral bulb lacking tumor / remote sentinel tumor / replication-competent pseudorabies virus / established glioma and other cancer / primary cancers / VSVrp30a infection / selective infection / few tumor / peripheral tumors / intravenously adsubcutaneous tumors / high-grade glioma cells / side shows infection / systemic delivery Gliomas / VSV infection / target brain tumors / Complete infection / high tumor / disseminated disease / VSVrp30a selectively infected tumor / Metastatic tumors / single tumor / intracranial tumors / widespread infection / SCID / glioblastoma surgery / widespread tumor / infected and killed tumor / brain cancer / multifocal brain tumors / single infiltrative tumor / malignant gliomas / high tumor-specific infection / rU87 glioma cell line / olfactory bulb tumors tumors / T- and B-cell-deficient SCID / infectious progeny / human lung carcinomas / / MedicalTreatment surgery / radiation / lobectomy / antibiotics / chemotherapy / / Organization Yale University Human Investigation Committee / Yale University Animal Care and Use Committee / Princeton University / Department of Neurosurgery / Society for Neuroscience / National Institute of Health / Yale Cancer Center / Yale University School of Medicine / Yale University / Ohio State University / Columbus / / Person Anthony N. van den Pol Koray / Guido Wollmann / Joseph M. Piepmeier / Anthony N. van den Pol / J. K. Rose / L. W. Enquist / R. Matthews / J. Rose / Evans Blue (Sigma) / K. R. Clark / D. D. Spencer / P. K. Ghosh / / Position RT / green fluorescent protein reporter / representative / SPOT-RT / reporter / / Product VSV injection / Evans Blue / Fluoview 300 / ammonium chloride / VSV / nude mice / rU87 / SCID mouse model / / ProvinceOrState Connecticut / / PublishedMedium The Journal of Neuroscience / / SportsEvent EPL / / Technology Neuroscience / radiation / conventional treatment technologies / apoptosis / Cell Signaling Technology / gene expression / chemotherapy / Neurosurgery / identical virus injection protocol / transplantation / laser / / SocialTag 
1882 • The Journal of Neuroscience, February 20, 2008 • 28(8):1882–1893 Neurobiology of Disease