| Document Date: 2014-06-04 14:49:21
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City Reference / / Company GlaxoSmithKline / / Currency pence / / Facility Clinic al Trials Experienc / / IndustryTerm other cancer therapies / imaging / food / Monitor for signs and symptoms / Other Cancer Therapy / / MedicalCondition adipocytic soft tissue sarcoma / altered taste / torsades de pointes / chest pain / headache / active infection / intracranial hemorrhage / chronic use / gastrointestinal stromal tumors / Dysfunction / cerebrovascular accident / thrombotic thrombocytopenic purpura / nausea / Serious infections / alopecia / hemoptysis / transient ischemic attack / embolus / subarachnoid hemorrhage / advanced soft tissue sar coma / fatigue / pulmonary / Cardiac dysfunction / gastrointestinal hemorrhage / ephalopathy Syndrome / diarrhea / advanced soft tissue sarcoma / hemolytic uremic syndrome / renal cell carcinoma / infections / blindness / Gilbert’s syndrome / dysgeusia / hea dache / Proteinuria / Abdominal pain / epistaxis / congestive heart failure / Hypertension / cancer / disease / dyspnea / Hypothyroidism / hematuria / dysgeusia / Carcinogenesis / neurological disorder / venous thrombosis / soft tissue sarcoma / neutropenia / Reversible Posterior Leukoencephalopathy Syndrome / lethargy / nephrotic syndrome / seizure / dysphonia / pain / vomiting / myocardial infarction / hepatic failure / cardiac disease / Infection / advanced renal cell carcinoma / fatal pulmonary emboli / / MedicalTreatment chemotherapy / surgery / cancer therapies / / MusicGroup Nausea / / OperatingSystem Dos / / Organization DOSAGE AND ADMINISTRATION / FDA / ded / / / Position mp / Major / / Product simvastatin / clarithromycin / rifampin / STS / ketoconazole / / ProvinceOrState Prince Edward Island / / PublishedMedium Baseline / / Technology magnetic resonance imaging / chemotherapy / treating cancer / Pharmacodynamics / / URL www.fda.gov/med / /
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• Venou s thromboembolic events (VTE) have been observed, including fatal pulmonary emboli (PE). Monitor for signs and symptoms of VTE and PE. (5.6) • Thrombotic microa ngiopathy (TMA), including thrombotic thrombo