| Document Date: 2014-01-15 19:42:22
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Company Biomarin / Sanofi Aventis / Humira Adalimumab MSP Abbott Laboratories / Enbrel Etanercept MSP Amgen Inc. / THOMSON REUTERS / CMR International / Alexion Pharmaceuticals / Genentech / Pfizer / Thomson Reuters Life Sciences Professional Services / GlaxoSmithKline / IMS Health / Reuters / Remicade Infliximab MSP Janssen Biotech Inc. / Manning & Napier / / Continent North America / / Country Japan / United States / Australia / Singapore / / Currency USD / / Event FDA Phase / Company Expansion / / IndustryTerm Non-orphan new chemical entities / information solutions / pharmaceutical industry / pharmaceutical measurement / pharmaceutical / mainstream pharmaceutical / treatment of two rare (orphan) diseases / pharmaceutical sales / pharmaceutical market value / generic pharmaceutical market / / MedicalCondition lymphoblastic leukemia TINDAMAX Tinidazole Bacterial vaginosis / rare diseases / lymphoma / chronic lymphocytic leukemia / heart disease / such diseases / rare life-threatening blood disease / LH deficiency / orphan diseases / orphan disease / additional rare diseases / disease / III Primary Pulmonary / rare disease / only one orphan disease / lower high cholesterol / hemoglobinuria / diseases / each disease / non-orphan indication rheumatoid arthritis / congenital short bowel APOKYN Apomorphine hydrochloride Parkinson’s disease / / MedicalTreatment eye surgery / drug therapy / / Organization European Organization for Rare Diseases / FDA / European Union / / Person Tobias Schwarz / Cory Williams / / Product Fluticasone Propionate / Humira / Herceptin / Acetaminophen / APOKYN / Rituxan / Acetylcysteine / CLOLAR / VIDAZA / Soliris / Remicade / Lipitor / NUTRESTORE / Newport Premium / Avastin / TINDAMAX / Cortellis THOMSON REUTERS 7 Orphan Drugs / Pentetate calcium trisodium / Cortellis / PENTETATE ZINC TRISODIUM / Enbrel / SENSIPAR / ACETADOTE / Clopidogrel / Plavix / Norvasc / VENTAVIS / Orphan Drug / LUVERIS / IMS / Thomson Reuters Cortellis / Discovery Today / / PublishedMedium Drug Discovery Today / / Technology Drug Discovery / drug development / /
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THE ECONOMIC POWER OF ORPHAN DRUGS Despite the smaller patient pool for rare disease R&D, the economics of