Houston / Philadelphia / Columbus / Bethesda / Charlottesville / Boston / New York / Washington / DC / San Diego / /
Company
Drug-Related Adverse Events Assigned Dose Group / Eastern Cooperative Oncology Group / Pharmaceuticals Inc / Kliewer SA / Martin AG / Dose-Limiting Toxicities Assigned Dose Group / Abbott Laboratories / 413 Group 2 Group / Disease (all patients; N ؍ 146) Group / Ligand Pharmaceuticals Inc / Roberts AB / Baseline Demographic Characteristics Group 1 Group 2 Group / Emergent Thyroid Function Test Abnormalities Assigned Dose Group / PD Group / Ligand Pharmaceuticals / Alteon Inc. / /
Currency
USD / pence / / /
Event
FDA Phase / Product Recall / Product Issues / /
Facility
University of Pennsylvania Cancer Center / Dana-Farber Cancer Institute / University of California Los Angeles / University of California San Francisco / Georgetown University / Memorial Sloan-Kettering Cancer Center / University of Michigan / University of Virginia / Cellular Oncology The University of Texas M.D. Anderson Cancer Center / National Cancer Institute / University of Texas M.D. Anderson Cancer Center / Baylor College of Medicine / University of Arkansas / /
IndustryTerm
therapy for stage IV metastatic breast cancer / hormonerefractory / treatment of acute promyelocytic leukemia / Treatment of breast cancer / treatment protocol / Therapy for Metastatic Breast Cancer / treatment of patients with metastatic breast cancer / chemotherapy-refractory / therapy for patients with progressive metastatic breast cancer / treatment of metastatic disease / tamoxifen-resistant / /
MedicalCondition
positive tumors / Central hypothyroidism / advanced breast cancer refractory / progressive metastatic breast cancer refractory / progressive metastatic breast cancer / coagulation disorder / thyroid disorder / metastatic disease / persistent early-stage cutaneous T-cell lymphoma / IV metastatic breast cancer / Once established tumors / diarrhea / advanced breast cancer / breast cancer / least stable disease / REAST CANCER / tumor / Cancer / tumors / arthralgia / hypothyroidism / established breast cancer / carcinogenesis / Hyperlipidemia Dry skin Asthenia Headache Nausea Rash Hypercholesteremia Diarrhea Exfoliative dermatitis Leucopenia Pruritus / neoplastic diseases / cutaneous lymphoma / bone metastases / breast tumors / pancreatitis / stable disease / rash / Joint pain / acute renal failure / hypercholesterolemia / mammary carcinogenesis / symptomatic visceral metastasis / total tumor / advanced disease / acute kidney failure / headache / hormone receptor positive tumors / carcinogen-induced rat mammary carcinomas / nausea / J Cancer / tamoxifen-resistance NMU-induced mammary tumor / metastatic breast cancer / acute promyelocytic leukemia / human promyelocytic leukemia / granulocytopenia / hyperlipemia / refractory advanced-stage cutaneous T-cell lymphoma / pruritus / human breast cancer / advanced breast carcinoma / lung metastases / rectal disorder / advanced non-small-cell lung cancer / sepsis / primary tumors / mammary carcinoma / cutaneous T-cell lymphoma / refractory metastatic breast cancer / disease / clinical hypothyroidism / hypertriglyceridemia / progressive disease / migraine / exfoliative dermatitis / chemotherapy-refractory metastatic breast cancer / severe hypertriglyceridemia / pain / Dose-Limiting Toxicity† Hyperlipemia Leucopenia Nausea Vomiting Rash Diarrhea LFTs / AIDSrelated Kaposi’s sarcoma / hypercalcemia / headache insomnia / vesiculobullous rash / carcinomas / progressive breast cancer / /
University of Michigan / Ann Arbor / University of California Los Angeles / Los Angeles / American Society of Clinical Oncology / University of Virginia / African Union / Baylor College of Medicine / University of Texas M.D. Anderson Cancer Center / National Cancer Institute / University of Arkansas / Dana-Farber Cancer Institute / University of California San Francisco / San Francisco / Georgetown University / Washington / Memorial Sloan-Kettering Cancer Center / University of Pennsylvania Cancer Center / Department of Health and Human Services / /
Person
John Glaspy / Leslie Laufman / Angela DeMichele / Valero V / Daniel F. Hayes / Gabriel N. Hortobagyi / Arch Derm / Maura Dickler / Francisco J. Esteva / C. Kent Osborne / Charles Brenton Huggins / George D. Demetri / Chen SR / Roger Cohen / Eric Winer / Richard C. Yocum / D. Demetri Purpose / Laura Hutchins / /
Multicenter Phase II Study of Oral Bexarotene for Patients With Metastatic Breast Cancer By Francisco J. Esteva, John Glaspy, Said Baidas, Leslie Laufman, Laura Hutchins, Maura Dickler, Debu Tripathy, Roger Cohen,