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Diabetes / Peptide hormones / Transcription factors / Eli Lilly and Company / Pancreatic hormones / PAX4 / Insulin / Pax genes / Diabetes mellitus type 1 / Biology / Endocrine system / Biochemistry


ORIGINAL ARTICLE In Vivo Conditional Pax4 Overexpression in Mature Islet b-Cells Prevents Stress-Induced Hyperglycemia in Mice Kai Hui Hu He,1 Petra I. Lorenzo,2 Thierry Brun,1 Carmen M. Jimenez Moreno,2 Deborah Aeberha
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Geneva / Uppsala / Exogenous / Nashville / Seville / St-Gallen / Basel / Rockford / Interestingly / Santa Cruz / /

Company

IgG / Sigma-Aldrich / 8D / Qiagen / Meda / Applera Europe / Primer Express Software / Novo Nordisk Pharma / GE Healthcare / BD Biosciences / K.H. HU HE AND ASSOCIATES / designed using the Primer Express Software / /

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Switzerland / Sweden / Guinea / Spain / /

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GBP / /

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Product Issues / /

Facility

University of Geneva / Vanderbilt University / University of Lausanne / /

IndustryTerm

immunoreactive products / culture media / noninvasive in vivo imaging / gene product / putative binding site / /

MedicalCondition

glucose intolerance / hyperglycemia DIABETES / ng/mL tumor necrosis / rapidly developed hyperglycemia / Pax4R129W mice diabetes / STZ- or diabetes / Mature Islet b-Cells Prevents Stress-Induced Hyperglycemia / obesity / GLUT2 diabetes / stress-induced hyperglycemia / http /

MedicalTreatment

Cell Therapy / /

NaturalFeature

Mature Islet / Pax4 islet / Pax4R129W islet / /

Organization

2Pancreatic Islet Development and Regeneration Unit / Regenerative Medicine / Juvenile Diabetes Research Foundation / Andalusian Center for Molecular Biology / Department of Stem Cells / Bertin Pharma Biotech Division / American Diabetes Association / Center for Integrative Genomics / Vanderbilt University / University of Geneva / Geneva / Andalusian Center for Molecular Biology and Regenerative Medicine / European Union / Swiss National Science Foundation / University of Lausanne / Lausanne / /

Person

Paloma Dominguez / Alexa Fluor / Benoit R. Gauthier / R. Stein / /

Position

Corresponding author / luciferase reporter / representative / reporter / /

Product

penicillin / glucagon / Sigma / doxycycline / STZ injection / IL-1b / glucose-induced insulin secretion / insulin secretion / /

ProvinceOrState

North Dakota / /

PublishedMedium

Molecular Biology / /

Technology

Genomics / Cell Therapy / antibodies / Stem Cells / DNA binding / apoptosis / gene expression / http / Regenerative Medicine / /

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http /

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