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Nutrition / Hyperglycemia / Reactive oxygen species / Paroxetine / Advanced glycation end-product / Diabetes management / Diabetes mellitus / Mitochondrion / Magnesium in biology / Chemistry / Biology / Diabetes


ORIGINAL ARTICLE Cell-Based Screening Identifies Paroxetine as an Inhibitor of Diabetic Endothelial Dysfunction Domokos Gerö, Petra Szoleczky, Kunihiro Suzuki, Katalin Módis, Gabor Oláh, Ciro Coletta, and Csaba Szab
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Galveston / Hercules / Newark / Ellisville / Madison / Billerica / Winooski / Melville / Gaylordsville / St. Louis / /

Company

MO TimTec LLC / D. GERÖ AND ASSOCIATES / Nikon / Seahorse Biosciences / ADP / Bio-Rad / /

Continent

Asia / Europe / /

Country

United States / /

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Event

FDA Phase / /

Facility

LOPAC1280 Library of Pharmacologically Active Compounds / Library NIH Clinical Collection FDA Approved Library Prestwick Chemical / library Change / Natural Products Library / University of Texas Medical Branch / Paroxetine building / /

IndustryTerm

end products / mouse mitochondrial energy / software package / aqueous solution / nonendothelial cell systems / cell-free systems / mitochondrial energy array / /

MedicalCondition

diabetes complications / nontoxic diabetes / hyperglycemic endothelial cell dysfunction / PAROXETINE PROTECTS FROM EC DYSFUNCTION / hyperglycemic endothelial cell injury / streptozotocin-induced diabetes / hyperglycemia/diabetes / hyperglycemic injury / PAROXETINE PROTECTS FROM EC DYSFUNCTION FIG / prototypical diabetes / diabetes.diabetesjournals.org DIABETES / endothelial dysfunction / hyperglycemia / diabetic endothelial dysfunction / Long-term hyperglycemia / diabetes / diabetic vascular dysfunction / secondary assay diabetes / diabetic microvascular and macrovascular disease / mmol/L hyperglycemia / /

MedicalTreatment

experimental therapy / relaxations / relaxation / /

NaturalFeature

Calcium channel / /

Organization

National Institute of Health / University of Texas Medical Branch / Food and Drug Administration / Department of Anesthesiology / American Diabetes Association / FDA / /

Person

Ciro Coletta / Petra Szoleczky / Katalin Módis / Gabor Oláh / Csaba Szabo / /

Position

thermo cycler / mediator / Corresponding author / Representative / /

Product

Methylprednisolone / penicillin / Dexamethasone / Flurandrenolide / Glimepiride / Flunisolide / mannitol / Tretinoin / MitoSOX Red / US Drug / bioactive / CFX96 / /

ProgrammingLanguage

EC / DC / /

ProvinceOrState

Texas / South Dakota / /

Technology

polymerization / OCR / Gene expression / http / gel electrophoresis / /

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http /

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