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NPC1 / Chemistry / Lipid storage disorders / Rare diseases / Steroids / Sterols / Cholesterol / Niemann–Pick disease / Low-density lipoprotein / Biology / Health / Transcription factors


Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1ⴚ/ⴚ mouse Benny Liua, Stephen D. Turleya, Dennis K. Burnsb, Anna M. Millerc, Joyce J. Repaa,c, a
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Document Date: 2009-08-07 14:59:34


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File Size: 1,26 MB

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City

Dallas / New York / Washington / DC / /

Company

Dana’s Angels Research Trust / McGraw-Hill / mCi / Suzuki / Christian AE / /

Currency

pence / /

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Event

Product Issues / /

Facility

University of Texas Southwestern Medical School / University of Texas Southwestern Medical Center / ScheringPlough Research Institute / /

IndustryTerm

stock solution / lysosomal processing / regulatory systems / activation energy / chemical digestion / experimental protocols / /

MedicalCondition

Niemann-Pick C1 disease / cellular cholesterol lipidosis / inflammatory factors / liver dysfunction / lung and liver disease / progressive neurological disease / pulmonary failure / organ dysfunction / MS / C (NPC) disease / NPC disease / disease / progressive liver disease / Niemann-Pick disease / liver and central nervous system disease / C disease / Inherited Disease / Wolman disease / Wolman disease/cholesteryl ester storage disease / /

NaturalFeature

Vanier MT / /

Organization

CYCLO Administration on Major Regulatory Mechanisms / University of Texas Southwestern Medical Center / Dallas / Ara Parseghian Medical Research Foundation / ScheringPlough Research Institute / Department of Internal Medicine / Institutional Animal Care and Use Committee / National Academy of Sciences / CYCLO Administration / University of Texas Southwestern Medical School / Moss Heart Fund / US Federal Reserve / Administration of CYCLO / s.c. administration / /

Person

Long-Term Effects / Harlan Teklad / Carolyn Smith / Anna M. Millerc / Stephen D. Turleya / Joyce J. Repaa / Kerry Foreman / Dennis K. Burnsb / Heather Waddell / Sean Campbell / Benny Liua / John M. Dietschya / /

Position

Haynes MP / Author / Representative / /

Product

Sigma / function / NPC1 / lysosomal transport / /

ProvinceOrState

Texas / New York / /

Technology

apoptosis / experimental protocols / Pharmacokinetics / /

URL

www.pnas.org兾cgi兾doi兾10.1073兾pnas.0810895106 / www.pnas.org/cgi/content/full / /

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