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Apolipoprotein B / RNA interference / Small interfering RNA / Stable nucleic acid lipid particle / Gene silencing / Low-density lipoprotein / Lipoprotein / Sense / Cholesterol / Biology / Genetics / RNA


doi:nature04688 LETTERS RNAi-mediated gene silencing in non-human primates Tracy S. Zimmermann1, Amy C. H. Lee2, Akin Akinc1, Birgit Bramlage3, David Bumcrot1, Matthew N. Fedoruk2,
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Document Date: 2015-03-05 19:45:49

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City

Oakville / Cambridge / Invitrogen / Kulmbach / /

Company

3Alnylam Europe AG / Academy Bio-Medical Company / Charles River Laboratories / Protiva Biotherapeutics Inc. / 2Protiva Biotherapeutics Inc. / Harlan Labs / Alnylam Pharmaceuticals Inc. / /

Country

Germany / United States / Canada / United Kingdom / /

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Event

FDA Phase / /

IndustryTerm

cleavage site / predicted cleavage site / online version / chemical conjugation / liposomal carrier / live-cell and live-animal bioluminescent imaging / /

MedicalCondition

lethal herpes simplex virus / acute coronary syndromes / disease / highly relevant and validated disease / coronary artery disease / infection / /

MedicalTreatment

statin therapy / /

Movie

D. V / A. D. / /

Organization

Canadian Council on Animal Care / National Science and Engineering Research Council of Canada / siRNA administration / Institutional Animal Care and Use Committee / i.v. administration / Administration of SNALP / /

Person

Ingo Ro / Morrissey / Gene Silencing / /

Position

Author / Author Information Reprints / MP / APOB messenger / Judge / /

Product

Cl / RNAi / SNALP / /

ProvinceOrState

Massachusetts / /

Technology

alpha / pharmacokinetics / ion exchange / specific delivery technologies / CDMA / antibodies / siRNA / Pharmacodynamics / /

URL

www.nature.com/nature / /

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