| Document Date: 2006-08-25 15:47:59
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City Melbourne / / Company Cancer Immunology Laboratory / Trescowthick Research Laboratories / / Country Australia / / / Event Product Issues / / Facility Peter MacCallum Cancer Institute / / IndustryTerm metabolic machinery / direct caspase processing / in vitro experimental systems / cytokine processing / / MedicalCondition REVIEWS Cytotoxic lymphocyte Cancer / causative infectious agent / Autoimmune diabetes / murine leukaemia virus / certain autoimmune diseases / perforin deficiency / MHC class-I-deficient tumours / ocular infection / aggressive mouse tumours / colon adenoma / spontaneous B-cell lymphoma / viral infection / human disorder / lymphoma / chronic and acute viral infection / chronic relapsing myelin oligodendrocyte glycoprotein / Autoimmune nephritis / unexplained fever / metastasis / epithelial cancer / graft-versus-host disease / experimental autoimmune encephalomyelitis / murine cytomegalovirus infection / carcinoma / significant osmotic injury / chronic LCMV infection / inflammatory cytokines / certain autoimmune disease / lymphadenopathy / spontaneous lung cancer / acute bacterial infection / overt viral infection / microbial infection / rapidly fatal / autosomal recessive immune disorder / breast carcinomas / mouse tumours / spontaneous lymphomas / infections / severe immune-mediated demyelinating disease / ectromelia infection / toxic injury / mammary carcinoma / autoimmune diseases / remarkably similar disease / nonlymphoid tumours / chemically induced sarcomas / NECROSIS A / Necrosis / insulin-dependent diabetes / Cancer / EBV-associated lymphoproliferative disease / disease / Mycobacterium tuberculosis / irradiated scid/scid / GRAFTVERSUS-HOST DISEASE / human cancer / contraction / tumour / histoplasmosis / chronic corneal inflammation / diabetes / melanomas / LCMV infection / fever / viral infections / pathogenesis The disorder / severe pancreatitis / initial infection / ectromelia virus / virus infection / intracellular bacterial infections / low-dose peripheral infection / autoimmune disease / diseases / NK-cell-sensitive tumours / ectromelia virus19 / lung adenocarcinomas / tBID Mitochondrion Mitochondrion Caspase activation Apoptosis Apoptosis GRAFT-VERSUS-HOST DISEASE / SCID / ectromelia / infection / carcinomas / inflammation / herpes simplex virus / infectious disease / B-cell lymphoma / FasL deficient Female infertility / prostate carcinoma / rare / congenital immune deficiency / lymphocytic choriomeningitis virus / tumours / methylcholanthrene-induced sarcomas / / MedicalTreatment immunization / adoptive transfer / bone-marrow transplant / Immunosuppression / / Organization Peter MacCallum Cancer Institute / / Person Mark J. Smyth Perforin / / Position model / crucial mediator / / Product TIL / granule exocytosis / signalling / donor / / ProgrammingLanguage DC / / Technology transplantation / apoptosis / condensation / Genotype / / URL www.nature.com/reviews/immunol / /
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REVIEWS FUNCTIONAL SIGNIFICANCE