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City Dallas / Minneapolis / WT / Welfare / Nagano / Nagoya / San Diego / Mountain View / San Jose / Santa Cruz / / Company Thermo Fisher / Filgen Inc / McDermott / Olympus / Boc / Sigma-Aldrich / Fujisawa / MERCK / Porter AG / Creative Commons / Macmillan Publishers Limited / / Country Japan / United States / / Currency pence / / / Event FDA Phase / / Facility Takemoto D. Plant / Chiba University / University of Tokyo / Whitehouse Station / Shinshu University / / / IndustryTerm gene products / / MedicalCondition inflammatory response / inflammatory cell death / autoinflammatory disease / neutrophilic urticarial rash / endotoxemia / melanoma / gout / characteristic programmed necrosis / Muckle-Wells autoinflammatory disorder / neutrophilic inflammatory response / caspase-1dependent necrosis / MS / familial cold autoinflammatory syndrome / Cryopyrin-associated periodic syndromes / Muckle-Wells syndrome / necrosis / cryopyrin-associated periodic syndrome / Disease / histamine-independent urticaria / neutrophil-rich inflammation / acute inflammation / tumor necrosis / inflammatory conditions / diseases / inflammation / neutrophilic inflammation T Satoh1 / / NaturalFeature Huang MT / / Organization Chiba University Animal Care and Use Committee / Department of Dermatology / Chiba University / University of Tokyo / Tokyo / A -1 / Shinshu University / Chiba University Graduate School / Ministry of Health / / Person Takeichi K et al. Diseaseassociated / AD AD V V / Karin M. Intracellular / Ann Rheum / / / Position Japan *Corresponding author / representative / / Product Sigma / doxycycline / M-16 / inh / IL-1b / it / / Technology antibodies / Cell Signaling / apoptosis / gene delivery / / URL http / SocialTag 
OPEN Citation: Cell Death and Disease[removed], e644; doi:[removed]cddis[removed] & 2013 Macmillan Publishers Limited All rights reserved[removed]www.nature.com/cddis