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Medicine / Research / Design of experiments / Bioethics / Medical ethics / Placebo / Pharmacometrics / Clinical trial / Antipsychotic / Pharmacology / Clinical research / Science


J Pharmacokinet Pharmacodyn DOI[removed]s10928[removed]ORIGINAL PAPER Development of a placebo effect model combined with a dropout
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City

Gainesville / New York / Washington / DC / Chicago / /

Company

Mallinckrodt / Kapcala LP / National Academies Press / /

Country

United States / /

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Facility

Chi square P Value / Hall KT / University of Florida / American College of Clinical Pharmacology / /

IndustryTerm

treatment of manic symptoms / drug development tool / biological tools / trial site / /

MedicalCondition

early Parkinson’s disease / major depressive disorder / Quantitative disease / Cephalalgia / bipolar disease / non-small-cell lung cancer / disorder / non-small cell lung cancer / psoriasis / neuropsychiatric disorders / tumor / treatable and recurrent psychiatric illness / Alzheimer’s disease / rapid disease / schizophrenia / slower disease / disease / exponential disease / longitudinal tumor / migraine / disorder Placebo model Dropout Clinical trial simulation Introduction Bipolar disorder / mania / pain / Parkinson’s disease / diseases / acute bipolar mania / linear disease / Methods Disease / acute schizophrenia / irritable bowel syndrome / depression / standard disease / bipolar disorder / /

Organization

USA H. Zhu Division of Clinical Pharmacology / National Research Council / USA G. Hochhaus Department of Pharmaceutics / French JL / US Food and Drug Administration / Division of Pharmacometrics / Houston JP / the American College / University of Florida / office of Clinical Pharmacology / T. P. Laughren Division of Psychiatry Products / /

Person

Silver Spring / Hao Zhu Guenther Hochhaus / Weibull / Thomas P. Laughren / /

Position

linear model / model development strategy / model / driver for the differential dropout rates / representative / joint model for nonlinear longitudinal data with informative dropout / Placebo dropout model / /

ProgrammingLanguage

C / /

ProvinceOrState

Florida / /

PublishedMedium

PLoS One / /

TVStation

Khin / /

Technology

pharmacokinetics / simulation / drug development / /

SocialTag