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Combretastatin / Angiogenesis / Vascular endothelial growth factor A / Cancer research / Enhanced permeability and retention effect / Proteases in angiogenesis / Medicine / Angiology / Vascular-targeting agent


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City

Ann Arbor / Paris / Tokyo / Boston / Macclesfield / Baguley / /

Company

Lee A. E. / Thomson / Kendall / Hill S. A. / Pfizer Inc. / Wilson / Aventis Pharma / VTAs / Simmons / Teikoku Hormone Mfg. / Ligand / Peregrine Pharmaceuticals Inc. / Suzuki / AstraZeneca / /

Country

France / Japan / United Kingdom / United States / /

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Event

FDA Phase / Business Partnership / /

Facility

University of Texas / Wayne State University / University of Texas Southwestern Medical Center / /

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IndustryTerm

magnetic resonance imaging / cancer therapy / cancer therapies / Cancer Therapeutics / noninvasive imaging / tumor energy status / as Cancer Therapeutics / treatment of cancer / noninvasive imaging methods / natural product / chemical crosslinkers / resonance imaging / noninvasive imaging section / transcription products / chemical / /

MedicalCondition

rat fibroblast tumor / solid tumours / massive central necrosis / Asymptomatic systolic hypotension / experimental tumors / urinary incontinence / mouse tumor / diphtheria / ligand-directed vascular targeting agents Class Examples Coagulation-inducing proteins Tissue factor Toxins Diphtheria / conventional antiproliferative cancer / human lung adenocarcinomas / human tumors / inflammatory mediators / experimental tumor / large / bulky tumours / differently regulated tumor / typical tumor / vasovagal syncope / colorectal liver metastases / complete tumor / massive tumor cell necrosis / reduced tumor / s.c. C38 colon adenocarcinoma / adenocarcinoma / specific tumor vessel thrombosis / tumor / large solid tumors / Cancer / advanced cancers / tumors / massive necrosis / shortness of breath / advanced solid tumors / experimental solid tumors / J. Cancer / widespread necrosis / experimental tumors CA4P / malignant disease / acute coronary syndrome / antiproliferative modalities lasting tumor / subsequent tumor / vomiting / extracellular matrix surrounding tumor / adrenocortical carcinoma / increased tumor / rapidly induced thrombosis / rapidly dividing tumor / hypokalemia / metastases / metastatic cervical carcinoma / reversible ataxia / G. M. The tumor / headache / established tumors / necrotic tumor / solid tumors / nausea / hemorrhagic necrosis / adjacent tumor / peripheral neuropathy / small tumors / fatigue / viable tumor / constipation / human breast cancer / modality cancer / mammary carcinoma / hyperkalemia / necrosis / different tumor / liver metastases / anaplastic thyroid cancer / rat rhabdomyosarcomas / dyspnea / human lung cancer / ischemia and extensive hemorrhagic necrosis / locally recurrent melanoma / solid tumor / extensive necrosis / contraction / tumour / pulmonary metastases / residual small tumor / mammary adenocarcinoma cell line / MCF7 breast tumor / advanced cancer / small experimental tumors / direct tumor / pain / tumor necrosis / chronic intermittent dosing / murine spontaneous tumors / aggressive murine tumors / inflammation / Thrombosis / experimental tumours / objective tumor / anemia / human lung tumor / D. W. Targeting the tumor / widespread central necrosis / massive tumor necrosis / /

MedicalTreatment

immunotherapy / radiation / cancer therapy / cancer therapies / radiation therapy / experimental therapies / radioimmunotherapy / gene therapy / Cancer Therapeutics / /

Organization

Wayne State University / Detroit / University of Texas Southwestern Medical Center / Dallas / Harold C. Simmons Comprehensive Cancer Center / CA4P administration / American Association for Cancer Research / DMXAA administration / University of Texas / Federal Aviation Administration / DMXAA / Department of Pharmacology / ZD6126 administration / Auckland Cancer Society Research Centre / AACR Publications Department / /

Person

Chaplin / Philip E. Thorpe Clin / Brien / Pettit / Van den Bogaert / Andy Ryan / Juliana Denekamp / Hennequin / Ralph Mason / Ogilvie / Thorpe Clin Cancer / David Blakey / Jeff Evelhoch / Philip E. Thorpe / /

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Position

D. J. / candidate for preclinical development / candidate for clinical trials / consultant / /

Product

carboplatin / cisplatin / Des / paclitaxel / acetic acid / cyclophosphamide / fluorouracil / ZD6126 / CA4P / AVE8062 / DMXAA / /

ProvinceOrState

British Columbia / Texas / /

PublishedMedium

Cancer Research / /

Technology

radiation / apoptosis / magnetic resonance imaging / gene expression / treating cancer / spectroscopy / genomics / tomography / antibodies / polymerization / ultrasound / cell signaling / MRI / gene therapy / phage display / be measured using 19F MRI / /

URL

http /

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