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Molecular biology / Proteins / DNA methyltransferase / Developmental biology / DNA methylation / Actin / K562 cells / Cellular differentiation / Histone deacetylase inhibitor / Biology / Genetics / Epigenetics


Anti-AML activity of combined epigenetic therapy with novel DNMT1 inhibitors SGI-110 and SGI1036 and histone deacetylase inhibitor panobinostat. Warren Fiskus1, Pace Johnston1, Rajeshree Joshi1, Rekha Rao1, Celalettin Us
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City

Pleasanton / Cambridge / /

Company

Novartis Pharmaceuticals / SuperGen Inc / USA 3SuperGen Inc. / /

Facility

PRC2 complex / Medical College of Georgia / /

MedicalCondition

leukemia / tumor / non-viable cells A. C. K562 cells K562 B. DNMT1 In myeloid leukemia / breast cancers / Cancer / CML blast crisis / human leukemia / tumor suppressor genes / bladder cancers / breast cancer / /

Organization

Redkar3 and Kapil Bhalla1 1MCG Cancer Center / Medical College of Georgia / /

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Product

Koss P15 Headphone/Headset / /

ProvinceOrState

Georgia / /

Technology

siRNA / gene expression / apoptosis / /

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