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Viruses / Programmed cell death / Cell signaling / Immune system / Reolysin / Oncolytics Biotech / Ras subfamily / Oncolytic virus / Apoptosis / Biology / Medicine / Cell biology


Reolysin is a novel reovirus-based agent that induces endoplasmic reticular stress-mediated apoptosis in pancreatic cancer
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Document Date: 2013-07-18 09:56:35


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File Size: 2,94 MB

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JEOL USA Inc. / Amersham / Oncolytics Biotech Inc. / 2Oncolytics Biotech Inc. / BD Biosciences / InCell Corp. / CellQuest Pro Software / Olympus / Jager R / Macmillan Publishers Limited / /

Country

Canada / United States / /

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pence / /

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FDA Phase / /

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University of Texas Health Science Center / Center Valley / University of Nebraska / /

IndustryTerm

cancer therapy / software version / therapy for cancer / viral products / chemicals / viral protein products / treatment of pancreatic cancer / saline solution / therapy for human pancreatic cancer / hydrogen peroxide solution / protein block solution / treatment of many cancer / /

MedicalCondition

fibrosarcoma cells / KRas-positive pancreatic tumors / JE / pancreatic tumors / significantly antagonized tumor / multiple myeloma cells / diverse tumor / colorectal liver metastases / non-small cell lung cancer / tumor / mitochondrial dysfunction / cancer / tumors / subcutaneous tumors / Institute P30 Cancer Center Support / advanced solid tumors / human cancer / pancreatic cancers / Ras-activated cancer / Ras-activated pancreatic cancer / infection / different cancer / oncolytic viral cancer / human pancreatic cancer / resistant cancers / reovirus infection / murine fibrosarcoma cells / Ras-activated cancers / Reolysin-treated tumors / head and neck cancer / viable tumor / MS / pancreatic cancer / Disease / murine malignant melanoma / advanced cancer / aggressive pancreatic tumors / pancreatic cancer JS Carew1 / Paraffin-embedded tumor / recurrent malignant gliomas / Mol Cancer / selective pancreatic cancer / mantle cell lymphoma cells / /

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radiotherapy / cancer therapy / Immunosuppression / cisplatin chemotherapy / radiation therapy / combination chemotherapy / chemotherapy / viral therapy / /

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Alpha / /

Organization

Institute for Drug Development / Department of Medicine / FDA / University of Texas Health Science Center at San Antonio / Medicine / Cancer Therapy and Research Center / University of Nebraska / Omaha / Cancer Therapy and Research Center / Ella Owens Foundation / /

Person

Alexa Fluor / Michel Ouellette / Arch Virol / /

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Position

mediator / Lolkema MP / Canada *Corresponding author / Voelcker Fund Young Investigator / important mediator / /

Product

carboplatin / cisplatin / Reolysin / paclitaxel / cyclophosphamide / HTC HD2 Smartphone / REO-10 / Reolysin(R) / /

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Nebraska / Alberta / Texas / South Dakota / /

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Gorman AM / /

Technology

radiation / siRNA / apoptosis / Cell Signaling Technology / gene expression / chemotherapy / treating cancer / gel electrophoresis / Alpha / Antibodies / Biotechnology / Drug Development / /

URL

www.nature.com/cddis / /

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