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Immune system / Extracellular matrix proteins / Rheumatology / Glycoproteins / Rheumatoid arthritis / Hyaluronan / Toll-like receptor / Lipopolysaccharide / Tumor necrosis factor-alpha / Biology / Anatomy / Cytokines


ARTICLES Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease © 2009 Nature America, Inc. All rights reserved.
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Document Date: 2010-02-12 10:42:33

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City

Epalinges / Allschwil / Strasbourg / Gutowski / London / /

Company

GraphPad Software / M 3 LP / Nature America Inc. / Gondokaryono S.P. / PBS FBG (µM) N LP / S LP / Actelion Pharmaceuticals Ltd. / S 0 LP / tenascin-C / Tnc / /

Continent

America / /

Country

Switzerland / France / United Kingdom / /

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Event

FDA Phase / /

Facility

Imperial College of Science / Institute of Child Health / University of Edinburgh / Scale bar / The Kennedy Institute of Rheumatology Trustees / UK National Institute / Hospital Hautepierre / Institute of Rheumatology Division / Kennedy Institute of Rheumatology Ethics Committee / /

IndustryTerm

online version / lipopolysaccharide binding site / ONLINE METHODS Materials / /

MedicalCondition

inflammatory response / autoimmune destructive arthritis / inflammatory arthritis / mild synovitis / sterile injury / arthritis / Zymosan-induced arthritis / joint disease / rheumatoid arthritis / tissue injury / collagen-induced arthritis / chronic inflammation / injury / multiple sclerosis / severe rheumatoid arthritis / Bone erosion Joint inflammation / destructive inflammatory joint disease / chronic proliferative arthritis / Zymosan-induced inflammation / I.R. Antigen-induced arthritis / acute inflammation / key inflammatory cytokines / chronic diabetic and venous ulcers / destructive arthritis / infection / knee joint inflammation / inflammatory and destructive processes / chronic inflammation17 / Joint inflammation / increased inflammation / chronic production / inflammatory cytokines / microbial infection / synovial inflammation / acute joint inflammation / sustained and erosive joint inflammation / inflammatory cells / erosive arthritis / inflammatory joint disease / Inflammatory cell infiltration / antigen-induced arthritis / well inflammatory activity / tumor necrosis factor-a / autoimmune diseases / erroneous inflammation / less joint inflammation / inflammatory loop / arthritic joint disease / disease / destructive joint inflammation / increased infectious risk / acute synovitis / extensive synovitis / severe inflammation / osteoarthritis / persistent synovial inflammation / primary Sjogren’s syndrome / synovitis / oral mucosal and inflammatory bowel disease17 / only mild inflammatory cell infiltration / persistent inflammatory cell infiltration / inflammatory and destructive mediators / inflammation / A.C. Zymosan-induced arthritis / murine antigen-induced arthritis / /

MedicalTreatment

immunization / /

Organization

UK National Institute / Riverside National Health Service Research Committee / Kennedy Institute / Institut National / UK Home Office / Universite´ Strasbourg / College of Science / University of Edinburgh / Institute of Child Health / Rheumatology Ethics Committee / PBS (PBS) / Faculty of Medicine / FBG PAM3 / Universite´ de Lausanne / Health Research Biomedical Research Centre / 1Kennedy Institute of Rheumatology Division / FBG PBS / Kennedy Institute of Rheumatology Trustees / /

Person

Nat / Kim / Maini / Paik / /

Position

D.J. / Representative / investigator / candidate for driving chronic inflammation / R.N. / /

Product

IL-8 / IL-6 / Mann-Whitney U / sterile water / TLR4 / /

ProvinceOrState

New Jersey / South Dakota / /

PublishedMedium

NATURE MEDICINE / /

Technology

gene expression / Crystallization / genotype / antibodies / DNA binding / /

URL

http /

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