Kano / Perryman / San Carlos / Cambridge / Pannu / /
Company
Protein Data Bank / Novartis Pharma AG / QUANTA / RLC / Vertex Pharmaceuticals Incorporated / Ligand / Bemis / Emerald Biosciences / Molecular Biology Inc. / Fujisawa / ADP / Lawrence Berkeley National Laboratory / Wilson / Thr / Ford / BIOMOL International L.P. / Chambers S. P. / Accelrys / Argonne National Laboratories / Lawrence Berkeley Laboratories / Shimizu / Suzuki / Coleman / Amersham Biosciences / Asahi Kasei / /
Country
Japan / United States / /
Currency
pence / / /
Event
FDA Phase / Business Partnership / /
Facility
ROCK complex / C terminus / ROCK/Y27632 complex / Rutgers University / N terminus / terminal Dimerization Domain / / /
IndustryTerm
active site / low energy conformations / replacement solution / side chain / isoquinoline methyl / metal / desired proteolytic product / protein stock solution / regulatory light chain / phosphorylation site / chemical cross-linking / hydroxyl / predicted phospho-threonine site / amine groups / light chain / /
Organization
Materials Sciences Division / Rutgers University / United States Department of Energy / office of Science / American Society for Biochemistry / office of Basic Energy Sciences / /
Person
Noble / Dotto / Lawson / Mark Fleming / Koto Hayakawa / Nat / Steven Bellon / Owen / Bush / Paul Taslimi / Hurley / Marc Jacobs / John Doran / Lora Swenson / / /
Position
D. J. / T. D. / Director / Hunter / Porter / G. P. / /
Product
polyethylene glycol / Fasudil / Y-27632 / /
ProvinceOrState
Nova Scotia / M. B. / Massachusetts / /
PublishedMedium
Molecular Biology / /
Technology
Bioinformatics / x-ray / Cloning / apoptosis / ion exchange / laser / crystallization / drug design / /
Protein Structure and Folding: The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity