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Company Phenotype-Guided Management / Mayo Medical Ventures / Genaissance Pharmaceuticals / Mayo Clinic Health Solutions / / Country United States / / Currency ATS / / Event Product Issues / FDA Phase / / IndustryTerm heterogeneous / / MedicalCondition rare multisystem disorders / heritable cardiac arrhythmia / Multisystem Long-QT Syndrome / lethal genetic disorder / sensorineural deafness / LQTS disease / torsades de pointes / periodic paralysis / recurrent cardiac arrest / simply ankyrin-B syndrome / syndactyly / sudden cardiac death / seizures / highly treatable genetic disorder / Congenital long QT syndrome / Andersen-Tawil syndrome / cardiac arrhythmias / sinus node dysfunction / bilateral sensorineural hearing loss / Timothy syndrome / cardiovascular disease / sick sinus syndrome / syncope / autism spectrum disorder / sudden cardiac arrest / atrioventricular block / deafness / SCD-predisposing cardiovascular disorders / heritable disorders / monogenic disorders / multisystem disorder / bradycardia / bilateral sensorineural deafness / congenital cardiac arrhythmia / hearing loss / disorders / long QT syndrome / / MedicalTreatment antibiotics / / Organization National Heart Lung and Blood Institute Ruth L. Kirschstein National Research Service / AR AD AD / / Person Melvin Scheinman / Ruth L. Kirschstein / John R.Giudicessi / Michael J. Ackerman / / Position Medical Scientist / Major / consultant / / Product triad / ketoconazole / erythromycin / thorazine / IK1 / KCNQ1 / IKs currents / LQT1 / JLN1 / KCNE2 / IKs / / Technology drug metabolism / Genotype / / URL http /
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Genotype- and Phenotype-Guided Management of Congenital Long QT Syndrome John R.Giudicessi, BA, and Michael J. Ackerman, MD, PhD Abstract: Congenital long QT syndrome (LQTS) is a genetically heterogeneous group of herita