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Ubiquitin / SCF complex / HECT domain / Cullin / Proteasome / CUL1 / Anaphase-promoting complex / Parkin / SKP2 / Biology / Proteins / Cell biology


Document Date: 2003-05-22 15:52:33

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City

Ring H2 / Cullin / Los Angeles / UCH / /

Company

Celgene / Wilson / Gwynne Hazen Cherry Memorial Laboratories / R.S. Annan S.A. / /

Country

United States / /

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Facility

VHL/Elongin/CUL2 complex / Anaphase Promoting Complex / E6/E6-AP complex / The SCFb-TRCP complex / terminus of Parkin / California Institute of Technology / Mattel Children’s Hospital / A complex / SCFb-TRCP complex / TRCP complex / SCF complex / /

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IndustryTerm

natural proteolytic machinery / metal binding ligands / machinery / chaperoned oncogene products / energy / impaired processing / gene products / potential clinical applications / e-amino / treatment of neurodegenerative disease / energy-dependent enzymatic pathway / potential therapeutic applications / gene product / metal-chelating residues / cellular degradation machinery / therapeutic applications / /

MedicalCondition

disease The VHL syndrome / same carcinomas / common autosomal recessive genetic disorder / HIV / Angelman syndrome Angelman syndrome / neurodegenerative disease / seizures / VHL syndrome / neurological disorders / autosomal recessive inherited disorder / renal cell carcinomas / tumor suppressor retinoblastoma / Huntington disease / rare neurological disorders / human diseases / squamous cell carcinomas / early onset hypertension / prostate cancer / metabolic disorders / Diabetes mellitus A / Williams syndrome / breast cancer / VHL disease / familial Parkinson disease / infantile liver disease / tumor / mental retardation / Clear cell renal carcinoma / cancer / tumors / nasopharyngeal carcinomas / Parkinson disease / emphysema / HPV / cervical cancer / hereditary form / lymphomas / viral infections / severe bronchopulmonary infections / hemangiomas / diseases / autoimmune polygladular syndrome / hypokalemia / cervical cancers / adenomatous polyposis coli / human papilloma virus E6 oncoprotein / severe insulin resistance / several diseases / autosomal dominant familial cancer syndrome / autosomal recessive juvenile Parkinsonism / Liddle syndrome / Leukemia associated-protein / severe liver disease / infections / neurodegenerative disorders / neurogenerative disorders / hypertension / common cancer / chronic neurodegenerative diseases / disease / pheochromocytomas / sporadic clear cell renal carcinomas / myeloid leukemias / cervical carcinoma / prion diseases / spinocerebellar ataxias / VHL tumors / p53 tumor / diabetes mellitus / autosomal dominant familial Parkinson disease / aggressive tumors / cerebellar hemangioblastomas / Alzheimer disease / neurodegenerative diseases / hepatic cirrhosis / human disease / /

MedicalTreatment

gene therapy / /

Organization

Jonsson Comprehensive Cancer Center / Mattel Children’s Hospital / Division of Hematology / David Geffen School of Medicine / UCLA / California Institute of Technology / Division of Biology / Department of Pathology / Department of Pediatrics / Leukemia and Lymphoma Society / National Academy of Sciences / /

Person

Nat / B.K. Kaiser / Craig Crews / Ray Deshaies / Frank Mercurio / Kathleen M. Sakamotoa / /

Position

engineer / messenger / /

Product

glycine / estradiol / testosterone / /

ProvinceOrState

California / /

Technology

PTCM technology / stem cells / apoptosis / gene expression / cell signaling / DNA binding / gene therapy / DNA synthesis / drug development / /

URL

www.academicpress.com / /

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