Chemistry / Tokyo / Lyon / Mountain View / St. Louis / Shanghai / Rockville / New York / Kowloon Tong / Cambridge / Beijing / San Diego / /
Company
BioVision Inc. / Lee SA / Sigma-Aldrich / Kunnumakkara AB / State Key Laboratory / Merck / GE Healthcare / Liu AG / Bio-Rad / ACS / low-FBS / Sino Biological Inc. / Creative Commons / Intel / Macmillan Publishers Limited / /
Country
France / China / United States / / /
Event
FDA Phase / /
Facility
Hong Kong Baptist University / C terminus / Hong Kong University of Science / University of Macau / Baptist University / Cha Chi-ming Science Tower / Ho Sin Hang Campus / State Key Laboratory of Quality Research / Institute of Chinese Medical Sciences / /
IndustryTerm
energy optimization / low-energy conformation / sub-site / cancer therapy / hydrophobic energy / analysis software / control / energy / pharmaceuticals / treatment of psoriasis / search area / chemical library containing / Energy calculations / chemical scaffolds / energy terms / natural product / energy potential maps / free energy / dual luciferase assay protocol / lowest-energy-binding poses / internal force field energy / e-pub / natural products / chemical library / local energy minimization / treatment of psoriasis52 and polycystic ovary syndrome / ml stop solution / drug treatment groups / polar and nonpolar solvation energy differences / electrostatic energy / Selective chemical probe inhibitor / lowest-energy-binding pose / ester / solvation energy / nonpolar and polar atom solvation energy differences / bioactive natural products / therapy for head and neck cancer / /
MedicalCondition
JE / multiple myeloma / mantle cell lymphoma cell lines / cancer inflammation / human melanoma / breast and lung cancer / melanoma / inflammatory bowel diseases / non-small cell lung cancer / human diseases / psoriasis / Stat3-dependent tumor / breast cancer / inflammatory diseases / leukemia / tumor / cancer / related tumor / bacterial infections / tumors / lymphomas / hyperandrogenism / osteosarcoma cells / DU145 prostate cancer / BMC Cancer / human hepatocellular carcinoma / Deficiency / tumours / human pancreatic cancer / metastasis / hematological malignancies / human cancers / interstitial fibrosis / head and neck cancer / pancreatic cancer / STAT3-induced tumor / Disease / osteosarcoma cell lines / polycystic ovary syndrome / Mol Cancer / inflammation / murine melanoma B16 tumor / /
Institute of Chinese Medical Sciences / Health and Medical Research Fund / Department of Chemistry / Hong Kong University of Science and Technology / Hong Kong / Science and Technology Development Fund / University of Macau / Research Grants Council / Centre for Cancer and Inflammation Research / Centre for Cancer / Association for Computing Machinery / School of Chinese Medicine / Hong Kong Baptist University / /
Person
Chem Commun / Prev Res / Ming-Yuen Lee / Wendy Yeung / Ann N Y Acad Sci / / /
Position
representative / chemist / central mediator / China *Corresponding author / molecular model for our investigations / reporter / /
Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening