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Alimentary Pharmacology and Therapeutics Duloxetine hepatotoxicity: a case-series from the drug-induced liver injury network R. Vuppalanchi*, P. H. Hayashi , N. Chalasani*, R. J. Fontanaà, H. Bonkovsky§, R. Saxena*,
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Document Date: 2014-11-18 16:35:58


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Ann Arbor / Greenberg / Bristol / Charlotte / Indianapolis / DILI / Kopanoff / Hunziker / Snider / Hellstrom / Daly / London / /

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Eli Lilly / Blackwell Publishing Ltd / Clinuvel Inc. / J&J / James LP / GlaxoSmithKline / Novartis Pharmaceuticals / Donaldson / Salix Pharmaceuticals / Abbott / Eli Lilly and Company / Gilead / Lundbeck SA. / Case / Teva / Vertex / KaroBio / /

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United States / /

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Arch Gen Psychiatry / National Institute of Diabetes / University of North Carolina / Laboratory of Pathology / University School / Initial laboratory / National Cancer Institute / Carolinas Medical Center / Chapel Hill / University of Arkansas / University of Michigan Medical School / /

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herbal products / imaging / pharmaceuticals / drug-induced liver injury network / treatment of major depressive disorder / /

MedicalCondition

diabetic neuropathy / alcohol abuse / rheumatoid arthritis / dysfunction / cirrhosis / hepatitis B / intrahepatic cholestasis / gout / centrilobular coagulative necrosis / injury / hepatitis / illness / liver disease / renal dysfunction / chronic leg / hepatic decompensation / renal injury / endocrine disorder / abdominal pain / pre-existing chronic liver disease / hypothyroidism / severe acute hepatic necrosis / Chronic / duloxetine-induced liver injury / Diabetes / HCV / Itching / fever / hepatic injury / anxiety disorder / vomiting / chronic alcoholism / patient and acute renal dysfunction / coronary artery disease / viral hepatitis / chronic hepatitis / renal failure / liver necrosis / depression / Rash / cholestasis / eosinophilia / hepatocellular injury / Inflammatory / HCV RNA / hepatitis A / major depressive disorder / Acute kidney failure / chest pain / significant liver injury / sciatica / Pre-existing medical conditions Underlying liver disease / nausea / Skin rash / thrombocytopenia / hepatitis C / fatigue / obesity / Prior drug allergies / renal failure resembling toxic liver injury / renal disease / mood disorders / hypersensitivity / back pain / Congestive heart failure / necrosis / suspected liver injury / disease / alcoholic liver disease / severe hepatic necrosis / chronic liver disease / Kidney Diseases / presumed nonalcoholic fatty liver disease / Neurological disease / upper abdominal pain / fulminant hepatic failure / pain / hepatic failure / drug-induced liver injury / liver injury / autoimmune hepatitis / acute hepatocellular injury / low back pain / inflammation / meningitis / either pre-existing liver disease / acute alcoholic hepatitis / syndrome / chronic hepatitis C / bipolar disorder / tuberculosis / /

MedicalTreatment

birth control / dietary supplements / antibiotics / drug therapy / gastric bypass surgery / adjuvant therapy / /

MusicGroup

Nausea / /

NaturalFeature

Chapel Hill / /

Organization

Cannon Research Center / Department of Internal Medicine / Division of Digestive Diseases and Nutrition / Laboratory of Pathology / Department of Medicine / National Institute of Diabetes and Digestive / FDA / Indiana University School of Medicine / National Cancer Institute / University of Michigan Medical School / University of North Carolina / University of Arkansas / Carolinas Medical Center / Center for Liver and Digestive Diseases / /

Person

Fontana / N. Chalasani / P. James / H. Bonkovsky / Clin Pediatr / R. Vuppalanchi / /

Position

advisor / author for the article / Major / Speaker / consultant / /

Product

acetaminophen / Cymbalta / clonazepam / allopurinol / ibuprofen / prednisone / cipro / mirtazapine / isoniazid / rifampin / /

ProvinceOrState

Alaska / Prince Edward Island / North Carolina / Arkansas / /

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genotype / antibodies / ultrasound / transplantation / /

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