| Document Date: 2012-08-31 09:36:34
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MedicalCondition tumor / paralysis / best tumor / pediatric brain tumors / true early progressive disease / pediatric brain stem gliomas / anaplastic astrocytoma / tumors / disease / fibrillary astrocytoma / Seizures / gangliogliomas / glioblastoma multiforme / typical intrinsic pontine gliomas / glioma / diffuse intrinsic pontine gliomas / pilomyxoid astrocytoma / dysfunction / neutropenia / thrombocytopenia / mixed gliomas / disseminated disease / seizure / refractory brain tumors / pulmonary / frozen tumor / gliosarcoma / anaplastic mixed glioma / brainstem tumors / juvenile pilocytic astrocytoma / Illness / infections / anaplasia / atypical pontine gliomas / / MedicalTreatment radiation treatment / radiation therapy / birth control / chemotherapy / surgery / radiation / / Position vp / treating physician / / Technology pharmacokinetics / radiation / ADC / chemotherapy / 2012 Protocol / 6 NCI Protocol / MRI / /
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NCI Protocol #: PBTC-033 Version Date: August 24, 2012 Protocol Abstract and Schema This is a phase I/II study to determine: 1) the maximum tolerated dose (MTD) or recommended phase II dose of ABT-888 in combination with