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City St. Louis / / Country Sweden / United States / / Currency pence / ATS / / Event Product Issues / / Facility Louis Children’s Hospital / University School / / IndustryTerm postsynthetic processing / machinery / active oxygen products / predominant site / hepatocyte transcriptional start site / reactive site / treatment of childhood metabolic liver disease / / MedicalCondition pseudomonas / primary liver cancer / common severe deficiency / dementia / liver dysfunction / clinically significant liver injury / significant liver injury / deficiency-associated liver disease / tissue injury / cirrhosis / hepatitis C / clinical disease / hepatitis B / only mild / subclinical pulmonary function abnormalities / injury / severe liver injury / clinical liver disease / lung disease / liver cell necrosis / periosinusoidal fibrosis / tissue injury/inflammation / severe liver disease / invasive hepatocellular carcinoma / PATHOGENESIS OF LIVER DISEASE / MECHANISM OF DEFICIENCY A / DEFICIENCY DAVID H. PERLMUTTER CLINICAL MANIFESTATIONS OF LIVER DISEASE / severe emphysema / dominantly inherited dementia / pruritus / liver disease / pulmonary emphysema / infections / inflammatory cell infiltration / human hepatoma cells / dissociation / hepatocellular necrosis / MECHANISM OF DEFICIENCY / liver and lung disease / very slowly progressing liver disease / Adenomas / genetic disease / clinically significant liver disease / disease / extrahepatic biliary atresia / hepatocellular carcinoma / relatively common disease / chronic liver disease / emphysema / childhood metabolic liver disease / genetic disorder / α1AT deficiency / genetic diseases / cholestatic clinical syndrome / portal hypertension / tumor necrosis factor / autoimmune disease / lung injury / diseases / systemic inflammation / infection / chronic hepatitis / pulmonary epithelial cells / deficiency / liver injury / autoimmune hepatitis / inflammation / MECHANISM OF LIVER CELL INJURY / thrombosis / hypercholesterolemia / fibrosis / enough liver injury / periportal fibrosis / / MedicalTreatment liver transplant / / Organization U.S. Securities and Exchange Commission / St. Louis Children’s Hospital / Washington University School of Medicine / Division of Gastroenterology and Nutrition / / Person DAVID H. PERLMUTTER / / Product secretion / / ProvinceOrState Missouri / / Technology X-ray / electrophoresis / hybridization / polymerization / directed mutagenesis / ATM / transplantation / genotype / / SocialTag 
48 α 1-ANTITRYPSIN DEFICIENCY DAVID H. PERLMUTTER CLINICAL MANIFESTATIONS OF LIVER DISEASE 700