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Water / Beta sheet / Hydrogen bond / Tetrahedral carbonyl addition compound / Serine protease / Tetrahedral molecular geometry / X-ray crystallography / Properties of water / Chemical bond / Chemistry / Chemical bonding / Protein structure


Published on Web[removed]Subangstrom Crystallography Reveals that Short Ionic Hydrogen Bonds, and Not a His-Asp Low-Barrier Hydrogen Bond, Stabilize the Transition State in Serine Protease Catalysis
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Document Date: 2006-09-05 18:44:46


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Rader / Rawlings / San Francisco / Cambridge / Sampson / Shenvi / New York / /

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Wilson / Pearson / Whitt S. A. / Mildvan A. S. / /

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United States / /

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Howard Hughes Medical Institute / EA complex / UniVersity of California / /

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active site / energy barrier / enzyme active site / vibrational energy level / lowest vibrational energy level / chemical shift / alcohol / energy profile / hydrogen-bonding network / energy barrier restricting hydrogen atom exchange / downfield 1H chemical shift / local water networks / energy / /

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Movement of Ser195 Makes His57 Ring Flipping Unnecessary / Department of Biochemistry and Biophysics / UniVersity of California / San Francisco / Howard Hughes Medical Institute / /

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David A. Agard / Structural Features / Matthew D. Daugherty / /

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D. J. / General / model representative / /

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Skullcandy G.I. Headphone/Headset / /

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His57 / South Dakota / His57.3 / New Jersey / peptide-associated41 / 42 / apoenyzme / 3 / 38 acylenzyme / 39 / 40 / North Dakota / Nova Scotia / California / A. B. / /

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9092 J. AM / 9090 J. AM / 9094 J. AM / 9088 J. AM / J. AM / 9 J. AM / /

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Krem / /

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radiation / X-ray / /

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