Dallas / Cruz Biotech / Cullin3 / Beijing / Los Angeles / /
Company
MicroCal Inc / TRAIL Ab / 3Joyant Pharmaceuticals / Qiagen / Wilson / BD Biosciences / Nature America Inc. / PerkinElmer / nt Co / IgG / Ligand / /
Country
Netherlands / China / United States / / /
Facility
C terminus / DR5 complex / Tianjin University / terminal Flag-tagged DR5 / DR5-expressing stable / TRAIL Ab +TRAIL Ab / DR5-overexpressing stable / Institute of Biological Sciences / University of California / US National Cancer Institute / University of Texas Southwestern Medical Center / μM TRAIL / TRAIL Bioymifi / /
IndustryTerm
chemical biology doi / online version / cancer therapy / chemical compound information / chemical structures / chemical biology / chemical components / proteolytic processing / chemical elucidation / immune signaling networks / therapy for cancer / light chain / buffer solutions / high-throughput chemical screen / chemical synthesis / ONLINE METHODS npg / cell imaging / chemical library / chemical identity / synthetic chemical compound / chemical syntheses / well-defined chemical entity / chemical library screen / synthetic chemical library / autocatalytic processing / /
MedicalCondition
clinical cancer / Xiaodong Wang4* Tumor necrosis factor / severe inflammatory response / Apo2 ligand/tumor necrosis / tumor / cancer / cervical cancer / human cancer / HCC15 lung cancer / malignant glioma / T98G human glioblastoma cells / human glioblastoma cell line / colon cancer / MS / human lung cancer / pancreatic carcinoma / high tumor / tumor necrosis / lung cancer / osteosarcoma cell line U2OS / /
MedicalTreatment
cancer therapy / anticancer therapies / anticancer therapy / /
Organization
4National Institute of Biological Sciences / University of Texas Southwestern Medical Center / Dallas / University of California / Origin Lab / National Natural Science Foundation of China / US National Cancer Institute / Department of Biochemistry / Tianjin University / Tianjin / /
Person
FR TN / Nat / Reverse Transcriptase (Invitrogen) / Lu Bioymifi / Xiaodong Wang / /
article published online: 23 december 2012 | doi: [removed]nchembio.1153 Small-molecule activation of the TRAIL receptor DR5 in human cancer cells